Compare perphenazine vs. trifluoperazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilafon
(perphenazine)

Stelazine
(trifluoperazine)

Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.Treats anxiety and schizophrenia. Stelazine (trifluoperazine) can be used to treat schizophrenia, but you might have trouble controlling your movements.
Reviews & ratings
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Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Stelazine (trifluoperazine)?
Worth itNot sureNot worth it
Side effects
perphenazinetrifluoperazine

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »

The trifluoperazine FDA package insert doesn’t have numbers about how common side effects are.

More about trifluoperazine side effects »
How it works
perphenazinetrifluoperazine
Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.Stelazine (trifluoperazine) is a first generation (typical) antipsychotic. It works in schizophrenia by making the brain less sensitive to changes in dopamine, which helps regulate your mood.
Type of medication
perphenazinetrifluoperazine
Prescription onlyPrescription only
Available as
perphenazinetrifluoperazine
  • Pill
  • Pill
Used for
perphenazinetrifluoperazine
Risk factors for serious side effects
perphenazinetrifluoperazine
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
  • People age 65 and older with dementia and psychosis
  • Women age 65 and older
  • Taking antipsychotic medications
  • History of low white or red blood cell counts
Detailed Stelazine (trifluoperazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
perphenazinetrifluoperazine
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
Sleep
perphenazinetrifluoperazine
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
No sleep related info.
Weight
perphenazinetrifluoperazine
  • You're more likely to gain weight.
No weight related info.
Upsides and benefits
perphenazinetrifluoperazine
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Stelazine (trifluoperazine) is one of the recommended medicines for schizophrenia.
  • It’s approved in children age 6 and older.
  • Available in generic.
  • Compared to other similar medicines, you're less likely to feel dehydrated or have problems with your heart with Stelazine (trifluoperazine).
Downsides and risks
perphenazinetrifluoperazine
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • If you take Stelazine (trifluoperazine) for more than 12 weeks or are taking high doses of Stelazine (trifluoperazine), you’re at a higher risk for being unable to control your movements.
  • Stelazine (trifluoperazine) can cause agitation and trouble sleeping. These symptoms can sometimes disappear, or there are other treatments you can take to help.
Tips from our pharmacists for people taking the medication
perphenazinetrifluoperazine
  • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
  • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
  • Take Trilafon (perphenazine) with food to avoid stomach upset.
  • Stelazine (trifluoperazine) can make you more sensitive to changes in temperature. If it's hot out, drink plenty of liquids, don't exercise too hard, and protect yourself from the sun. If it's cold, dress warm and don't stay outside too long.
  • Stelazine (trifluoperazine) can make you feel sleepy for the first few days. Don't drive or do anything requiring concentration until you know how it affects you.
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
  • You might feel dizzy or faint the first few days you take Stelazine (trifluoperazine). Be very careful getting up if you've been sitting or lying down for a while.
  • If you want to stop taking Stelazine (trifluoperazine) and you've been taking it for at least a few months, talk to your doctor first.
Learn more
More about perphenazineSide effectsAlternativesFDA package insert
Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
More about trifluoperazineSide effectsAlternativesFDA package insert
Have you used Stelazine (trifluoperazine)?
Worth itNot sureNot worth it