Compare Phenergan vs. Compro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Phenergan
(Promethazine)

Compro
(Prochlorperazine)

Helps you feel less queasy. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.96969696969697Phenergan
Reviews for Phenergan (Promethazine)
79%
of people say Phenergan (Promethazine) is worth it
73%
say it works well
3%
say it's a big hassle
Reviews for Compro (Prochlorperazine)
45%
34% vs. Phenergan (Promethazine)
35%
38% vs. Phenergan (Promethazine)
35%
32% vs. Phenergan (Promethazine)
Side effects
PhenerganCompro

The Phenergan FDA package insert doesn’t have numbers about how common side effects are.

More about Phenergan side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
How it works
PhenerganCompro
Phenergan (Promethazine) is an antihistamine, which helps control allergies. It also seems to block your body's natural reflex for vomiting, which makes it useful as an antiemetic (anti-nausea medicine).Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
PhenerganCompro
Anti-nausea
Antihistamine
Prescription only
Anti-nausea, Antipsychotic
Antidopaminergic
Prescription only
Available as
PhenerganCompro
  • Pill
  • Liquid
  • Suppository
  • Pill
  • Suppository
Used for (click to learn more)
PhenerganCompro
Risk factors for serious side effects
PhenerganCompro
  • Children under 2 years of age
  • History of seizures
    • Age over 65
      Detailed Phenergan (Promethazine) risks & warnings »
      • Over age 65
      • Dementia
      • Taking antipsychotics
      • History of seizures
      • Age over 65
          • Taking with alcohol
          • Taking other medicines that make you less alert
          Detailed Compro (Prochlorperazine) risks & warnings »
          Pregnancy category
          PhenerganCompro
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          NFDA pregnancy category (Unknown)

          The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

          See the FDA package insert
          Alcohol
          • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
          • Don't drink alcohol to avoid intense side effects.
          • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
          • Don't drink alcohol to avoid intense side effects.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.
          • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          PhenerganCompro
          • Available in generic.
          • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
          • Available in generic, so it's cheap.
          • Can be taken by mouth, as a shot, or rectally.
          • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
          Downsides and risks
          PhenerganCompro
          • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
          • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
          • Can make your skin more sensitive to the sun.
          • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
          • Can't be used by people over 65 because they can be more affected by the side effects.
          • It can make you more likely to get heatstroke.
          Tips from our pharmacists for people taking the medication
          PhenerganCompro
          • Promethazine comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
          • Don't give to kids 2 and under.
          • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
          • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
          • Don't drink alcohol to avoid intense side effects.
          • Avoid using if you experience seizures (epilepsy).
          • Don't use if you're 65 or older because you're at higher risk for serious side effects.
          • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
          • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
          • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
          • Don't drink alcohol to avoid intense side effects.
          • Avoid using if you experience seizures (epilepsy).
          • Don't use if you're 65 or older because you're at higher risk for serious side effects.
          Learn more
          More about PhenerganSide effectsReviews & ratingsAlternativesFDA package insert
          More about ComproSide effectsReviews & ratingsAlternativesFDA package insert