Compare Phenergan vs. Compro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Phenergan (Promethazine)

Prescription only

Compro (Prochlorperazine)

Prescription only
Helps you feel less queasy.

Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.

4.4/ 5 average rating with 38 reviewsforPhenergan
Helps you feel less queasy.

Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.

3.0/ 5 average rating with 20 reviewsforCompro
Upsides
  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
Downsides
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.
Used for
Dosage forms
  • Pill
  • Liquid
  • Suppository
  • Pill
  • Suppository
Price
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Reviews
38 reviews so far
82%
saidit'sworth it
76%
saiditworked well
5%
saidit'sa big hassle

Have you used Phenergan (Promethazine)?

Leave a review
20 reviews so far
45%
saidit'sworth it
35%
saiditworked well
35%
saidit'sa big hassle

Have you used Compro (Prochlorperazine)?

Leave a review
Side effects
The Phenergan (Promethazine) FDA package insert doesn’t have numbers about how common side effects are.
The Compro (Prochlorperazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Slowing or stopping of breathing
    • Children under 2 years of age
  • Seizures
    • History of seizures
  • Sunburn
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
See more detailed risks and warnings
  • Increased risk of death
    • Over age 65
    • Dementia
    • Taking antipsychotics
  • Seizures
    • History of seizures
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
  • Heatstroke
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings