Compare Phenergan vs. Scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Phenergan
(promethazine)

Transderm-Scop
(scopolamine)

Helps you feel less queasy. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.Helps you feel less queasy. Transderm-Scop (Scopolamine) works well to prevent nausea and vomiting and the patch is low-hassle, but it takes about 4 hours to kick in.
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Coupons for Phenergan
Best available price for 20 (25mg) tablets of promethazine
Coupons for Scopolamine
Best available price for 4 (1.5mg) patches of scopolamine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
6.08Phenergan
Reviews for Phenergan (promethazine)
82%
of people (All ages) say Phenergan (promethazine) is worth it
76%
say it works well
5%
say it's a big hassle
Have you used Phenergan (promethazine)?
Worth itNot sureNot worth it
Reviews for Transderm-Scop (scopolamine)
73%
-9% worse vs. Phenergan (promethazine)
58%
-18% worse vs. Phenergan (promethazine)
19%
-14% worse vs. Phenergan (promethazine)
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it
Side effects
PhenerganScopolamine

The Phenergan FDA package insert doesn’t have numbers about how common side effects are.

More about Phenergan side effects »
  • Dry mouth 66%
  • Dizziness 17%
  • Any side effect 10%
  • Drowsiness 4%
  • Agitation 2%
  • Visual impairment 2%
  • Confusion 1%
  • Dilated pupil 4%
  • Sore throat 1%
More Scopolamine side effects »
How it works
PhenerganScopolamine
Phenergan (Promethazine) is an antihistamine, which helps control allergies. It also seems to block your body's natural reflex for vomiting, which makes it useful as an antiemetic (anti-nausea medicine).Transderm-Scop (Scopolamine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
PhenerganScopolamine
Prescription only
Prescription only
Available as
PhenerganScopolamine
  • Pill
  • Liquid
  • Suppository
  • Patch
Used for
PhenerganScopolamine
Risk factors for serious side effects
PhenerganScopolamine
  • Children under 2 years of age
  • History of seizures
  • Age over 65
Detailed Phenergan (promethazine) risks & warnings »
  • Glaucoma
  • Doing an MRI
  • History of seizures
  • History of psychosis
  • Taking with alcohol
Detailed Transderm-Scop (scopolamine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
PhenerganScopolamine
  • Don't drink alcohol to avoid intense side effects.
  • You have to avoid alcohol while on the medication.
  • Don't drink alcohol if you have to use the patch.
Pain
PhenerganScopolamine
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
No pain related info.
Sleep
PhenerganScopolamine
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
No sleep related info.
Upsides and benefits
PhenerganScopolamine
  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
  • Even though there's no generic version available, it's inexpensive.
  • Placed on the skin so it can be used if you can't keep anything in your stomach.
  • Can be used for long-term control of nausea and vomiting since it's only placed on every 3 days.
Downsides and risks
PhenerganScopolamine
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.
  • Can only be used to prevent nausea and vomiting, not to treat it if it's already happening.
  • Takes about 4 hours for it to start working.
  • You have to avoid alcohol while on the medication.
Tips from our pharmacists for people taking the medication
PhenerganScopolamine
  • Promethazine comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
  • Don't give to kids 2 and under.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
  • Don't drink alcohol to avoid intense side effects.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
  • Avoid using if you experience seizures (epilepsy).
  • Don't use if you're 65 or older because you're at higher risk for serious side effects.
  • Wash your hands after you place the patch.
  • Don't touch or rub your eyes after putting on the patch before washing your hands.
  • Can cause blurry vision and sleepiness.
  • Take the patch off if you have to do an MRI.
  • Don't drink alcohol if you have to use the patch.
  • Place it on a few hours before if you know you'll be in a place where you might get motion sickness.
Learn more
More about PhenerganSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Phenergan (promethazine)?
Worth itNot sureNot worth it
More about ScopolamineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Transderm-Scop (scopolamine)?
Worth itNot sureNot worth it