Compare Phenergan vs. scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Helps you feel less queasy.

Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.

4.4/ 5 average rating with 38 reviewsforPhenergan
Prevents nausea and vomiting.

Transderm-Scop (scopolamine) is a low-hassle patch that works well to prevent nausea and vomiting, but it takes several hours to work.

3.9/ 5 average rating with 26 reviewsforscopolamine
Upsides
  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
  • Transderm-Scop (scopolamine) is well tolerated.
  • Prevents nausea for 3 days.
  • Because Transderm-Scop (scopolamine) is a skin patch, it's a good alternative to stopping nausea and vomiting if you're not able to swallow pills.
Downsides
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.
  • Can only be used for prevention of nausea and vomiting. It can't stop nausea or vomiting that's already happening.
  • The side effects can be worse if you are 65 and older.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
  • You're more likely to have heat stroke or feel dehydrated.
  • It takes a few hours for Transderm-Scop (scopolamine) to kick in, so you have to remember to take it beforehand.
Used for
Dosage forms
  • Pill
  • Liquid
  • Suppository
  • Patch
Price
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Reviews
38 reviews so far
82%
saidit'sworth it
76%
saiditworked well
5%
saidit'sa big hassle

Have you used Phenergan (Promethazine)?

Leave a review
26 reviews so far
73%
saidit'sworth it
58%
saiditworked well
19%
saidit'sa big hassle

Have you used Transderm-Scop (scopolamine)?

Leave a review
Side effects
The Phenergan (Promethazine) FDA package insert doesn’t have numbers about how common side effects are.
The Transderm-Scop (scopolamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Slowing or stopping of breathing
    • Children under 2 years of age
  • Seizures
    • History of seizures
  • Sunburn
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
See more detailed risks and warnings
  • Increased pressure in the eyes
    • Open angle glaucoma
  • Worsening stomach, bowel, or bladder blockages
    • Blockages in the stomach, bowels or bladder
  • Skin burns
    • MRI examination
  • Heat stroke
  • Worsening seizures or psychosis
    • History of seizures
    • History of psychosis
  • Sleepiness and dizziness
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings