Compare Phenylephrine vs. Advil Allergy And Congestion Relief

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Clears your sinuses.

Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.

3.1/ 5 average rating with 164 reviewsforPhenylephrine
Relieves cold and allergy symptoms.

Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.

3.6/ 5 average rating with 1437 reviewsforAdvil Allergy And Congestion Relief
Upsides
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
Used for
Dosage forms
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
  • Pill
Price
No pricing information available
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Reviews
164 reviews so far
44%
saidit'sworth it
24%
saiditworked well
10%
saidit'sa big hassle

Have you used Sudafed Pe (Phenylephrine)?

Leave a review
1437 reviews so far
73%
saidit'sworth it
30%
saiditworked well
6%
saidit'sa big hassle

Have you used Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)?

Leave a review
Side effects
The Sudafed Pe (Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Heart problems
    • History of heart problems
    • Age 65 years or older
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Stomach bleeding
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Harm to fetus
    • Women of childbearing age
  • Lower kidney function
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking high blood pressure medications
    • Age 65 years or older
  • High blood pressure
    • History of high blood pressure
  • Heart attack or stroke
    • History of heart problems
    • Age 65 years or older
    • Taking with aspirin
See more detailed risks and warnings