Compare Phenylephrine vs. Allegra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sudafed Pe
(phenylephrine)

Allegra
(fexofenadine)

Clears your sinuses. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.18Phenylephrine
Reviews for Phenylephrine
44%
of people (All ages) say Phenylephrine is worth it
24%
say it works well
10%
say it's a big hassle
164 reviews
Have you used Sudafed Pe (phenylephrine)?
Worth itNot sureNot worth it
Reviews for Allegra
79%
-35% worse vs. Phenylephrine
63%
-39% worse vs. Phenylephrine
0%
-10% worse vs. Phenylephrine
Have you used Allegra (fexofenadine)?
Worth itNot sureNot worth it
Side effects
PhenylephrineAllegra

We haven’t found good data for Phenylephrine side effects.

FDA side effect reports for Phenylephrine »
  • Dysmenorrhea 2%
  • Headache 3%
  • Back Pain 2%
  • Cough 3%
  • Upper Respiratory Tract Infection 2%
  • Pyrexia 1%
  • Otitis Media 2%
  • Rhinorrhea 1%
More Allegra side effects »
How it works
PhenylephrineAllegra
Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.
Type of medication
PhenylephrineAllegra
Prescription or OTCPrescription or OTC
Available as
PhenylephrineAllegra
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
  • Pill
  • Dissolving tablet
  • Liquid
Used for
PhenylephrineAllegra
Risk factors for serious side effects
PhenylephrineAllegra
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of heart problems
  • Age 65 years or older
  • Women of childbearing age
Detailed Sudafed Pe (phenylephrine) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed Allegra (fexofenadine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
PhenylephrineAllegra
No food related info.
  • Some forms of Allegra (Fexofenadine) contain aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, check to see which products you can use.
Kidneys and liver
PhenylephrineAllegra
No kidneys and liver related info.
  • The dose needs to be adjusted for people with kidney problems.
Sleep
PhenylephrineAllegra
No sleep related info.
  • Can make you feel dizzy or sleepy, so you can take it at bedtime.
  • Won't make you feel drowsy like some antihistamine medicines.
Upsides and benefits
PhenylephrineAllegra
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
  • Relieves allergy symptoms, like sneezing, runny nose, and itching.
  • Approved to be used in kids and adults age 6 months and older.
  • Won't make you feel drowsy like some antihistamine medicines.
  • Available over-the-counter without a prescription.
  • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
  • It's okay to take with most other medications since it has very few interactions.
Downsides and risks
PhenylephrineAllegra
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
  • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
  • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
  • The dose needs to be adjusted for people with kidney problems.
Tips from our pharmacists for people taking the medication
PhenylephrineAllegra
  • Starts working in 30 minutes.
  • Phenylephrine can make you restless, so don't take it too close to bedtime.
  • It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Starts working in 1 to 2 hours depending on what dosage form you're taking.
  • Works best when taken regularly, even before symptoms are expected to appear.
  • Can make you feel dizzy or sleepy, so you can take it at bedtime.
  • Follow age-specific dosing and don't take more than recommended.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
Learn more
More about PhenylephrineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Sudafed Pe (phenylephrine)?
Worth itNot sureNot worth it
More about AllegraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Allegra (fexofenadine)?
Worth itNot sureNot worth it