Compare Phenylephrine vs. Allegra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sudafed Pe (Phenylephrine)

Prescription or OTC

Allegra (fexofenadine)

Over-the-counter
Clears your sinuses.

Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.

3.1/ 5 average rating with 164 reviewsforPhenylephrine
Treats allergy symptoms.

Allegra (fexofenadine) relieves allergy symptoms without making you feel drowsy.

3.9/ 5 average rating with 24 reviewsforAllegra
Upsides
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
  • Allegra (fexofenadine) is effective at reducing symptoms for seasonal allergies and chronic hives without significant drowsiness, unlike Benadryl.
  • Approved for kids aged 6 months or older.
  • Allegra (fexofenadine) comes in many forms, like tablet, liquid, and quick-dissolving tablet.
Downsides
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
  • Allegra (fexofenadine)'s effectiveness can wear off over time.
  • The dose needs to be adjusted for people with kidney problems.
Used for
Dosage forms
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
  • Pill
  • Dissolving tablet
  • Liquid
Price
No pricing information available
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Reviews
164 reviews so far
44%
saidit'sworth it
24%
saiditworked well
10%
saidit'sa big hassle

Have you used Sudafed Pe (Phenylephrine)?

Leave a review
24 reviews so far
79%
saidit'sworth it
63%
saiditworked well
0%
saidit'sa big hassle

Have you used Allegra (fexofenadine)?

Leave a review
Side effects
The Sudafed Pe (Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Dizziness
    2%
  • Back Pain
    2%
  • Stomach discomfort
    2%
  • Pain in hands/feet
    2%
See more detailed side effects
Risks and risk factors
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Heart problems
    • History of heart problems
    • Age 65 years or older
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Brain damage from too much phenylalanine
    • History of phenylketonuria (PKU)
See more detailed risks and warnings