Compare Phenylephrine vs. Nasonex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sudafed Pe
(Phenylephrine)

Nasonex
(Mometasone)

Clears your sinuses. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.Relieves allergy symptoms. Nasonex (Mometasone) is a good first-choice treatment for stuffy and runny noses caused by allergies.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.171779141104294Phenylephrine
Reviews for Sudafed Pe (Phenylephrine)
44%
of people say Sudafed Pe (Phenylephrine) is worth it
23%
say it works well
10%
say it's a big hassle
Reviews for Nasonex (Mometasone)
68%
+24% vs. Sudafed Pe (Phenylephrine)
38%
+15% vs. Sudafed Pe (Phenylephrine)
8%
+2% vs. Sudafed Pe (Phenylephrine)
Side effects
PhenylephrineNasonex

We haven’t found good data for Phenylephrine side effects.

FDA side effect reports for Phenylephrine »
  • Nosebleed 8%
  • Headache 4%
  • Viral infection 3%
  • Menstrual cramps 2%
  • Sinus inflammation 2%
  • Musculoskeletal pain 2%
  • Sore throat 2%
  • Coughing 1%
  • Vomiting 1%
More Nasonex side effects »
How it works
PhenylephrineNasonex
Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Nasonex (Mometasone) is a topical steroid. It works directly where it's applied to help reduce swelling and inflammation in your nose.
Type of medication
PhenylephrineNasonex
DecongestantPrescription or OTC
Anti-inflammatory
Corticosteroid
Prescription only
Available as
PhenylephrineNasonex
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
  • Nasal spray
Used for (click to learn more)
PhenylephrineNasonex
Risk factors for serious side effects
PhenylephrineNasonex
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of heart problems
  • Age 65 years or older
  • Women of childbearing age
Detailed Sudafed Pe (Phenylephrine) risks & warnings »
  • Long-term use
  • Long-term use
  • Surgery or trauma to the nose or sinuses
  • Long-term use
  • Exposure to immunizable diseases (chickenpox and measles)
  • Exposure to tuberculosis
  • Long-term use
  • Taking more than recommended dose
Detailed Nasonex (Mometasone) risks & warnings »
Pregnancy category
PhenylephrineNasonex
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Shouldn't use it before you want to sleep.
No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
PhenylephrineNasonex
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
  • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
  • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
  • Can be used as needed to help control symptoms in people age 13 years or older.
  • Available as a generic, which is cheaper.
Downsides and risks
PhenylephrineNasonex
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
  • Needs to be primed 10 times before it can be used, or re-primed if not used for more than 2 weeks.
  • Doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
  • Since the medicine in Nasonex (Mometasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
Tips from our pharmacists for people taking the medication
PhenylephrineNasonex
  • Starts working in 30 minutes.
  • Phenylephrine can make you restless, so don't take it too close to bedtime.
  • It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Use Nasonex (Mometasone) once a day, following age-specific recommendations on how many sprays to use. Don't take more than prescribed.
  • Blow your nose before using.
  • Can cause thrush (a fungal infection) inside your nose and throat. Can also cause nosebleeds, a sore throat, and headaches.
  • Needs to be used regularly during allergy season for it to work. It can take 1 to 2 weeks for the medicine to start working fully.
  • Check with your doctor or pharmacist on how to use the nasal spray the right way.
  • Shake well before using it. Before the first use, prime the bottle by spraying it until you see a fine mist.
Learn more
More about PhenylephrineSide effectsReviews & ratingsAlternativesFDA package insert
More about NasonexSide effectsReviews & ratingsAlternativesFDA package insert