Compare Phenylephrine vs. Tylenol Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Clears your sinuses.

Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.

3.1/ 5 average rating with 164 reviewsforPhenylephrine
Relieves pain and congestion.

Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.

3.6/ 5 average rating with 1176 reviewsforTylenol Sinus
Upsides
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
Downsides
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
Used for
Dosage forms
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
  • Pill
Price
No pricing information available
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Reviews
164 reviews so far
44%
saidit'sworth it
24%
saiditworked well
10%
saidit'sa big hassle

Have you used Sudafed Pe (Phenylephrine)?

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1176 reviews so far
74%
saidit'sworth it
31%
saiditworked well
5%
saidit'sa big hassle

Have you used Tylenol Sinus (Acetaminophen / Phenylephrine)?

Leave a review
Side effects
The Sudafed Pe (Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Tylenol Sinus (Acetaminophen / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Heart problems
    • History of heart problems
    • Age 65 years or older
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings