Compare Plavix vs. Aspirin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plavix (clopidogrel)

Prescription only

Aspirin

Over-the-counter
Prevents blood clots.

Plavix (clopidogrel) is a cheap, generically available blood thinner that protects you from clots after you've had a heart attack or surgery.

5.0/ 7 average rating with 343 reviewsforPlavix
Relieves pain, fever, and inflammation. Protects your heart and thins blood.

A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.

5.2/ 7 average rating with 533 reviewsforAspirin
Upsides
  • Plavix (clopidogrel) can help lower your risk of getting a stroke or heart attack.
  • You only need to take it once a day.
  • A genetic test is available to determine whether Plavix (clopidogrel) will be an effective treatment option for you.
  • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
  • Used in higher doses to relieve pain, swelling, and fever.
  • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
Downsides
  • Raises your risk of bleeding and bruising, which can be serious and life-threatening.
  • May not be safe to be taken with many other medicines or supplements.
  • If you've taken too much Plavix (clopidogrel) and you're bleeding, plasma transfusions are required to stop the bleeding.
  • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
  • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
  • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
  • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$9.9
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Reviews
343 
59%
think this treatment is worth it
49%
think this treatment works well
16%
think this treatment is a hassle

Have you used Plavix (clopidogrel)?

Leave a review
533 
76%
think this treatment is worth it
41%
think this treatment works well
6%
think this treatment is a hassle

Have you used Aspirin?

Leave a review
Side effects
The Plavix (clopidogrel) FDA package insert doesn’t have numbers about how common side effects are.
The Aspirin FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Weakened ability to prevent blood clots

    Taking Prilosec or Nexium

    ...and 1 more risk factors

  • Life-threatening bleeding

    History of stomach bleeding

    ...and 2 more risk factors

See more detailed risks and warnings
  • Brain damage or death from Reye's Syndrome

    Children 18 years or younger

    ...and 1 more risk factors

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

  • Harm to unborn babies

    Women of childbearing age

See more detailed risks and warnings