Compare Plavix vs. Aspirin

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.
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Reviews & ratings
Filter group. All currently selected
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Reviews for Plavix (Clopidogrel)
of people (All ages) say Plavix (Clopidogrel) is worth it
say it works well
say it's a big hassle
339 reviews
Have you used Plavix (Clopidogrel)?
Worth itNot sureNot worth it
Reviews for Aspirin
+17% vs. Plavix (Clopidogrel)
8% vs. Plavix (Clopidogrel)
+10% vs. Plavix (Clopidogrel)
532 reviews
Have you used Aspirin?
Worth itNot sureNot worth it
Side effects
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »
How it works
Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.
Type of medication
Prescription only
Pain reliever
Available as
  • Pill
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Liver problems
  • Drug interactions
  • Certain genetic disposition
    Detailed Plavix (Clopidogrel) risks & warnings »
    • Children 18 years or younger
    • Children recovering from viral infections
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking Aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
    • Women of childbearing age
    Detailed Aspirin risks & warnings »
    Pregnancy category
    No specific food related info.
    • Take with food to lower the chance of an upset stomach.
    Upsides and benefits
    • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
    • Studies have shown clopidogrel lowers your risk of death or further heart complications.
    • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
    • Used in higher doses to relieve pain, swelling, and fever.
    • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
    Downsides and risks
    • Raises your risk of bleeding and bruising.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Doesn't work well for people with certain genetic variations.
    • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
    • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
    • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
    • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
    Tips from our pharmacists for people taking the medication
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • Can raise your risk of bleeding or bruising.
    • Take it exactly as instructed.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
    • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
    • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
    • Take with food to lower the chance of an upset stomach.
    • Don't use for kids younger than 18 years old.
    • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
    Learn more
    More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Plavix (Clopidogrel)?
    Worth itNot sureNot worth it
    More about AspirinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Aspirin?
    Worth itNot sureNot worth it