Compare Plavix vs. Aspirin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plavix
(Clopidogrel)

Aspirin

Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.002949852507375Plavix
Reviews for Plavix (Clopidogrel)
59%
of people say Plavix (Clopidogrel) is worth it
49%
say it works well
16%
say it's a big hassle
Reviews for Aspirin
76%
+17% vs. Plavix (Clopidogrel)
41%
8% vs. Plavix (Clopidogrel)
6%
+10% vs. Plavix (Clopidogrel)
Side effects
PlavixAspirin
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »
How it works
PlavixAspirin
Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.
Type of medication
PlavixAspirin
Anticoagulant
Anti-platelet
Prescription only
Pain reliever
Salicylate
Anticoagulant
Anti-platelet
Over-the-counter
Available as
PlavixAspirin
  • Pill
  • Pill
Used for (click to learn more)
PlavixAspirin
Risk factors for serious side effects
PlavixAspirin
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Liver problems
  • Drug interactions
  • Certain genetic disposition
    Detailed Plavix (Clopidogrel) risks & warnings »
    • Children 18 years or younger
    • Children recovering from viral infections
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking Aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
    • Women of childbearing age
    Detailed Aspirin risks & warnings »
    Pregnancy category
    PlavixAspirin
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • Take with food to lower the chance of an upset stomach.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    PlavixAspirin
    • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
    • Studies have shown clopidogrel lowers your risk of death or further heart complications.
    • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
    • Used in higher doses to relieve pain, swelling, and fever.
    • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
    Downsides and risks
    PlavixAspirin
    • Raises your risk of bleeding and bruising.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Doesn't work well for people with certain genetic variations.
    • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
    • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
    • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
    • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
    Tips from our pharmacists for people taking the medication
    PlavixAspirin
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • Can raise your risk of bleeding or bruising.
    • Take it exactly as instructed.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
    • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
    • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
    • Take with food to lower the chance of an upset stomach.
    • Don't use for kids younger than 18 years old.
    • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
    Learn more
    More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
    More about AspirinSide effectsReviews & ratingsAlternativesFDA package insert