Compare Plavix vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plavix (clopidogrel)

Prescription only

Coumadin (warfarin)

Prescription only
Prevents blood clots.

Plavix (clopidogrel) is a cheap, generically available blood thinner that protects you from clots after you've had a heart attack or surgery.

3.7/ 5 average rating with 343 reviewsforPlavix
Prevents blood clots.

Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.

3.8/ 5 average rating with 513 reviewsforCoumadin
Upsides
  • Plavix (clopidogrel) can help lower your risk of getting a stroke or heart attack.
  • You only need to take it once a day.
  • A genetic test is available to determine whether Plavix (clopidogrel) will be an effective treatment option for you.
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
Downsides
  • Raises your risk of bleeding and bruising, which can be serious and life-threatening.
  • May not be safe to be taken with many other medicines or supplements.
  • If you've taken too much Plavix (clopidogrel) and you're bleeding, plasma transfusions are required to stop the bleeding.
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
343 reviews so far
59%
saidit'sworth it
49%
saiditworked well
16%
saidit'sa big hassle

Have you used Plavix (clopidogrel)?

Leave a review
513 reviews so far
61%
saidit'sworth it
54%
saiditworked well
21%
saidit'sa big hassle

Have you used Coumadin (warfarin)?

Leave a review
Side effects
The Plavix (clopidogrel) FDA package insert doesn’t have numbers about how common side effects are.
The Coumadin (warfarin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Weakened ability to prevent blood clots
    • Taking Prilosec or Nexium
    • People with certain genes that make Plavix (clopidogrel) less effective
  • Life-threatening bleeding
    • History of stomach bleeding
    • Taking other medicines that increase the levels of Plavix (clopidogrel) in your body
    • Taking other blood thinners or medicines that increase the risk of bleeding
  • Unexplained bruising and purple spots on skin
See more detailed risks and warnings
  • Life threatening bleeding
    • Coumadin (warfarin) dose too high
    • Age greater than 65 year
    • History of stomach bleeding
    • High blood pressure
    • Kidney or liver problems
    • Drug interactions
    • Change in lifestyle or diet
    • Alcohol use
    • Certain genetic factors
  • Harm to fetus
    • Women of childbearing age
  • Drug and diet interactions
  • Potential surgery or amputation
See more detailed risks and warnings