Compare Plavix vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plavix
(clopidogrel)

Coumadin
(warfarin)

Prevents blood clots. Plavix (clopidogrel) is a cheap, generically available blood thinner that protects you from clots after you've had a heart attack or surgery.Prevents blood clots. Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5Plavix
Reviews for Plavix
59%
of people (All ages) say Plavix is worth it
49%
say it works well
16%
say it's a big hassle
343 reviews
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it
Reviews for Coumadin
61%
-2% worse vs. Plavix
54%
-5% worse vs. Plavix
21%
+5% better vs. Plavix
513 reviews
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it
Side effects
PlavixCoumadin
  • Minor bleeding 3%
  • Major bleeding 1%
More Plavix side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
PlavixCoumadin
Plavix (clopidogrel) is an antiplatelet blood thinner. It stops platelets in your blood from clumping together which makes it harder for them to form clots.Coumadin (warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.
Type of medication
PlavixCoumadin
Prescription onlyPrescription only
Available as
PlavixCoumadin
  • Pill
  • Pill
Used for
PlavixCoumadin
Risk factors for serious side effects
PlavixCoumadin
  • Taking Prilosec or Nexium
  • People with certain genes that make Plavix (clopidogrel) less effective
  • History of stomach bleeding
  • Taking other medicines that increase the levels of Plavix (clopidogrel) in your body
  • Taking other blood thinners or medicines that increase the risk of bleeding
Detailed Plavix (clopidogrel) risks & warnings »
  • Coumadin (warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
Detailed Coumadin (warfarin) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
PlavixCoumadin
No interactions related info.
  • Coumadin (warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Upsides and benefits
PlavixCoumadin
  • Plavix (clopidogrel) can help lower your risk of getting a stroke or heart attack.
  • You only need to take it once a day.
  • A genetic test is available to determine whether Plavix (clopidogrel) will be an effective treatment option for you.
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
Downsides and risks
PlavixCoumadin
  • Raises your risk of bleeding and bruising, which can be serious and life-threatening.
  • May not be safe to be taken with many other medicines or supplements.
  • If you've taken too much Plavix (clopidogrel) and you're bleeding, plasma transfusions are required to stop the bleeding.
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Tips from our pharmacists for people taking the medication
PlavixCoumadin
  • Thins your blood to prevent clots from forming or getting bigger.
  • Can raise your risk of bleeding or bruising.
  • Take this medicine exactly as told by your doctor.
  • Plavix (clopidogrel) may not be safe to be taken together with some medicines and over-the-counter supplements. Don't start any new medicine without first speaking with your doctor or pharmacist.
  • Let your doctor know right away if you experience a fever, weakness, or unusual bleeding and bruising.
  • You should stop taking Plavix (clopidogrel) at least 5 days before any major surgeries to lower your chances of bleeding.
  • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
  • Take Coumadin (warfarin) exactly as your doctor tells you.
  • Once you're taking Coumadin (warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
  • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (warfarin) in case you have a medical emergency.
  • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (warfarin).
  • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
Learn more
More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it
More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it