Compare Plavix vs. Lovenox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.
How it works
Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.
Type of medication
Prescription only
Prescription only
Available as
  • Pill
  • Injection
Used for (click to learn more)
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Reviews & ratings
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Reviews for Plavix (Clopidogrel)
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Side effects
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »
  • Injection site hematoma 7%
  • Fever 2%
  • Confusion 1%
  • Nausea 1%
More Lovenox side effects »
Risk factors for serious side effects
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Liver problems
  • Drug interactions
  • Certain genetic disposition
    Detailed Plavix (Clopidogrel) risks & warnings »
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
    • Taking NSAIDs or other blood thinning medicines
    • History of bleeding problems
    • Severe high blood pressure
    • Older age
    • Stopping Lovenox (Enoxaparin) early
    • Heparin-induced thrombocytopenia
    Detailed Lovenox (Enoxaparin) risks & warnings »
    Pregnancy category
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
    • Studies have shown clopidogrel lowers your risk of death or further heart complications.
    • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
    • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
    • Available in generic so it can be cheaper than other "blood thinners".
    • Good option if you're pregnant or have cancer.
    Downsides and risks
    • Raises your risk of bleeding and bruising.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Doesn't work well for people with certain genetic variations.
    • It is only available as an injection, so it's not great if you're afraid of needles.
    • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
    • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
    Tips from our pharmacists for people taking the medication
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • Can raise your risk of bleeding or bruising.
    • Take it exactly as instructed.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
    • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
    • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
    • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
    • Can cause swelling in your legs, diarrhea, and nausea.
    Learn more
    More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
    More about LovenoxSide effectsReviews & ratingsAlternativesFDA package insert