Compare Plendil vs. Catapres

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plendil
(Felodipine)

Catapres
(Clonidine)

Lowers blood pressure. Plendil (Felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
Reviews for Catapres (Clonidine)
42%
8% vs. Plendil (Felodipine)
33%
17% vs. Plendil (Felodipine)
35%
+15% vs. Plendil (Felodipine)
Have you used Catapres (Clonidine)?
Worth itNot sureNot worth it
Side effects
PlendilCatapres
  • Swelling 14%
  • Flushing 6%
  • Headache 5%
  • Upset stomach 3%
  • Racing heart beat 2%
  • Colds or flu 2%
  • Dizziness 1%
  • Weakness 1%
  • Constipation 1%
  • Nausea 1%
More Plendil side effects »

The Catapres FDA package insert doesn’t have numbers about how common side effects are.

More about Catapres side effects »
How it works
PlendilCatapres
Plendil (Felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.
Type of medication
PlendilCatapres
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Alpha agonist
Prescription only
Available as
PlendilCatapres
  • Extended release
  • Pill
  • Extended release
  • Patch
Used for (click to learn more)
PlendilCatapres
Risk factors for serious side effects
PlendilCatapres
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • History of heart failure
  • History of kidney disease
Detailed risks & warnings »
  • Sudden discontinuation of medicine
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
PlendilCatapres
  • Plendil (Felodipine) can be taken without food or with a light low fat meal.
No food related info.
Sleep
PlendilCatapres
No sleep related info.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
Upsides and benefits
PlendilCatapres
  • Plendil (Felodipine) is a good option for people with high blood pressure.
  • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Available in a weekly patch for people that aren't good at taking medicine by mouth.
  • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
  • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
Downsides and risks
PlendilCatapres
  • Plendil (Felodipine) may not work as well as other calcium channel blockers.
  • It can lead to more swelling in your arms and legs when taken at higher doses.
  • You can't miss doses. Stopping Plendil (Felodipine) could cause a sudden spike in blood pressure.
  • Plendil (Felodipine) can't be crushed or cut into two.
  • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
  • The pill form can make some people sleepy, dizzy, and have dry mouth.
  • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
PlendilCatapres
  • Can cause swelling in your legs or ankles.
  • Can also cause swelling in your gums.
  • Plendil (Felodipine) can be taken without food or with a light low fat meal.
  • Avoid grapefruit and grapefruit juice while taking Plendil (Felodipine).
  • You might feel lightheaded or dizzy when first starting Plendil (Felodipine).
  • Usually taken together with other medicines for better blood pressure control.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • If side effects don't go away, talk to your doctor about alternatives.
  • The weekly patch form can have fewer side effects.
  • Don't stop taking this medicine suddenly.
  • Extended release tablet also used to treat ADHD.
Learn more
More about PlendilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
More about CatapresSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Catapres (Clonidine)?
Worth itNot sureNot worth it