Compare Plendil vs. Coreg

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plendil
(Felodipine)

Coreg
(Carvedilol)

Lowers blood pressure. Plendil (Felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.Lowers blood pressure and controls heart rate. Coreg (Carvedilol) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.
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Reviews & ratings
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Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
Reviews for Coreg (Carvedilol)
53%
+3% better vs. Plendil (Felodipine)
46%
-4% worse vs. Plendil (Felodipine)
18%
+32% better vs. Plendil (Felodipine)
406 reviews
Have you used Coreg (Carvedilol)?
Worth itNot sureNot worth it
Side effects
PlendilCoreg
  • Headache 1%
  • Flushing 3%
  • Upset stomach 3%
  • Weakness 1%
  • Colds or flu 2%
  • Runny nose 2%
  • Sneezing 2%
  • Rash 1%
More Plendil side effects »
  • Dizziness 13%
  • Fatigue 2%
  • High blood sugar 4%
  • Diarrhea 6%
  • Weight increase 3%
  • Nausea 4%
  • Abnormally slow heartbeat 8%
  • Low blood pressure 6%
  • Headache 1%
More Coreg side effects »
How it works
PlendilCoreg
Plendil (Felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.Coreg (Carvedilol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
PlendilCoreg
Prescription only
Prescription only
Available as
PlendilCoreg
  • Extended release
  • Pill
  • Extended release
Used for
PlendilCoreg
Risk factors for serious side effects
PlendilCoreg
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • Over age 65
  • History of heart failure
  • History of kidney disease
Detailed Plendil (Felodipine) risks & warnings »
  • Abrupt discontinuation of Coreg (Carvedilol)
      • Congestive heart failure
      • Increasing the dose of Coreg (Carvedilol)
      • Diabetes
      • Major surgery requiring anesthesia
        Detailed Coreg (Carvedilol) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Food
        PlendilCoreg
        • Plendil (Felodipine) can be taken without food or with a light low fat meal.
        • You have to take Carvedilol with food.
        • Take it with food.
        Upsides and benefits
        PlendilCoreg
        • Plendil (Felodipine) is a good option for people with high blood pressure.
        • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
        • A first-choice treatment to prevent chest pain (angina).
        • A first-choice treatment for heart failure and heart attack.
        • For people with severe heart failure, Carvedilol lowers the risk of worsening heart failure, hospitalization, and sudden death.
        Downsides and risks
        PlendilCoreg
        • Plendil (Felodipine) may not work as well as other calcium channel blockers.
        • It can lead to more swelling in your arms and legs when taken at higher doses.
        • You can't miss doses. Stopping Plendil (Felodipine) could cause a sudden spike in blood pressure.
        • Plendil (Felodipine) can't be crushed or cut into two.
        • You have to take Carvedilol with food.
        • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
        • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
        • Can hide symptoms of low blood sugar if you're diabetic.
        • You can't miss doses. Stopping Carvedilol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
        Tips from our pharmacists for people taking the medication
        PlendilCoreg
        • Can cause swelling in your legs or ankles.
        • Can also cause swelling in your gums.
        • Plendil (Felodipine) can be taken without food or with a light low fat meal.
        • Avoid grapefruit and grapefruit juice while taking Plendil (Felodipine).
        • You might feel lightheaded or dizzy when first starting Plendil (Felodipine).
        • Take it with food.
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Can cause fatigue and erectile dysfunction.
        • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
        • Don't stop taking this medicine suddenly.
        Learn more
        More about PlendilSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Plendil (Felodipine)?
        Worth itNot sureNot worth it
        More about CoregSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Coreg (Carvedilol)?
        Worth itNot sureNot worth it