Compare Plendil vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plendil
(Felodipine)

Microzide
(Hydrochlorothiazide )

Lowers blood pressure. Plendil (Felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
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Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
-3% worse vs. Plendil (Felodipine)
31%
-19% worse vs. Plendil (Felodipine)
16%
+34% better vs. Plendil (Felodipine)
139 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it
Side effects
PlendilHydrochlorothiazide
  • Headache 1%
  • Flushing 3%
  • Upset stomach 3%
  • Weakness 1%
  • Colds or flu 2%
  • Runny nose 2%
  • Sneezing 2%
  • Rash 1%
More Plendil side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
PlendilHydrochlorothiazide
Plendil (Felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
PlendilHydrochlorothiazide
Prescription only
Prescription only
Available as
PlendilHydrochlorothiazide
  • Extended release
  • Pill
Used for
PlendilHydrochlorothiazide
Risk factors for serious side effects
PlendilHydrochlorothiazide
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • Over age 65
  • History of heart failure
  • History of kidney disease
Detailed Plendil (Felodipine) risks & warnings »
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    PlendilHydrochlorothiazide
    • Plendil (Felodipine) can be taken without food or with a light low fat meal.
    No food related info.
    Kidneys and liver
    PlendilHydrochlorothiazide
    No kidneys and liver related info.
    • Requires routine blood tests to check kidney function.
    Upsides and benefits
    PlendilHydrochlorothiazide
    • Plendil (Felodipine) is a good option for people with high blood pressure.
    • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    Downsides and risks
    PlendilHydrochlorothiazide
    • Plendil (Felodipine) may not work as well as other calcium channel blockers.
    • It can lead to more swelling in your arms and legs when taken at higher doses.
    • You can't miss doses. Stopping Plendil (Felodipine) could cause a sudden spike in blood pressure.
    • Plendil (Felodipine) can't be crushed or cut into two.
    • Makes you urinate more often.
    • Doesn't work well in people with severe kidney problems.
    Tips from our pharmacists for people taking the medication
    PlendilHydrochlorothiazide
    • Can cause swelling in your legs or ankles.
    • Can also cause swelling in your gums.
    • Plendil (Felodipine) can be taken without food or with a light low fat meal.
    • Avoid grapefruit and grapefruit juice while taking Plendil (Felodipine).
    • You might feel lightheaded or dizzy when first starting Plendil (Felodipine).
    • Starts working in about 2 hours.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    Learn more
    More about PlendilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Plendil (Felodipine)?
    Worth itNot sureNot worth it
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Microzide (Hydrochlorothiazide (Hctz))?
    Worth itNot sureNot worth it