Plendil vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Scroll horizontally → to see comparisons


(Hydrochlorothiazide )

Coming soon.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
How it works
Coming soon.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
Coming soon.
Prescription only
Available as
  • Extended release
  • Pill
Used for (click to learn more)
  • Hypertension
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Microzide (Hydrochlorothiazide (Hctz))
-3% vs. Plendil (Felodipine)
-19% vs. Plendil (Felodipine)
+35% vs. Plendil (Felodipine)
Side effects

We haven’t found good data for Plendil side effects.

FDA side effect reports for Plendil »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
Risk factors for serious side effects
Coming soon.
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    Pregnancy category
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • Doesn't work well in people with severe kidney problems.
    • Requires routine blood tests to check kidney function.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    Coming soon.
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    Downsides and risks
    Coming soon.
    • Makes you urinate more often.
    • Doesn't work well in people with severe kidney problems.
    Tips from our pharmacists for people taking the medication
    Coming soon.
    • Starts working in about 2 hours.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    Learn more
    More about PlendilSide effectsReviews & ratingsFDA package insert
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert