Compare Plendil vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plendil
(Felodipine)

Zestril
(Lisinopril)

Lowers blood pressure. Plendil (Felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
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Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
Reviews for Zestril (Lisinopril)
61%
+11% vs. Plendil (Felodipine)
51%
+1% vs. Plendil (Felodipine)
14%
+36% vs. Plendil (Felodipine)
687 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Side effects
PlendilLisinopril
  • Swelling 14%
  • Flushing 6%
  • Headache 5%
  • Upset stomach 3%
  • Racing heart beat 2%
  • Colds or flu 2%
  • Dizziness 1%
  • Weakness 1%
  • Constipation 1%
  • Nausea 1%
More Plendil side effects »

The Lisinopril FDA package insert doesn’t have numbers about how common side effects are.

More about Lisinopril side effects »
How it works
PlendilLisinopril
Plendil (Felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
PlendilLisinopril
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
ACE inhibitor
Prescription only
Available as
PlendilLisinopril
  • Extended release
  • Pill
Used for (click to learn more)
PlendilLisinopril
Risk factors for serious side effects
PlendilLisinopril
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • History of heart failure
  • History of kidney disease
Detailed risks & warnings »
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
PlendilLisinopril
  • Plendil (Felodipine) can be taken without food or with a light low fat meal.
No food related info.
Kidneys and liver
PlendilLisinopril
No kidneys and liver related info.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
Upsides and benefits
PlendilLisinopril
  • Plendil (Felodipine) is a good option for people with high blood pressure.
  • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
Downsides and risks
PlendilLisinopril
  • Plendil (Felodipine) may not work as well as other calcium channel blockers.
  • It can lead to more swelling in your arms and legs when taken at higher doses.
  • You can't miss doses. Stopping Plendil (Felodipine) could cause a sudden spike in blood pressure.
  • Plendil (Felodipine) can't be crushed or cut into two.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
PlendilLisinopril
  • Can cause swelling in your legs or ankles.
  • Can also cause swelling in your gums.
  • Plendil (Felodipine) can be taken without food or with a light low fat meal.
  • Avoid grapefruit and grapefruit juice while taking Plendil (Felodipine).
  • You might feel lightheaded or dizzy when first starting Plendil (Felodipine).
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
Learn more
More about PlendilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it