Compare Plendil vs. Lopressor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plendil
(Felodipine)

Lopressor
(Metoprolol Tartrate)

Lowers blood pressure. Plendil (Felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.Lowers blood pressure and controls heart rate. Lopressor (Metoprolol Tartrate) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.
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Reviews & ratings
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Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
Reviews for Lopressor (Metoprolol Tartrate)
62%
+12% better vs. Plendil (Felodipine)
47%
-3% worse vs. Plendil (Felodipine)
15%
+35% better vs. Plendil (Felodipine)
464 reviews
Have you used Lopressor (Metoprolol Tartrate)?
Worth itNot sureNot worth it
Side effects
PlendilLopressor
  • Headache 1%
  • Flushing 3%
  • Upset stomach 3%
  • Weakness 1%
  • Colds or flu 2%
  • Runny nose 2%
  • Sneezing 2%
  • Rash 1%
More Plendil side effects »
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Diarrhea 5%
  • Itching 5%
  • Shortness of breath 3%
  • Abnormally slow heartbeat 3%
  • Low blood pressure 4%
More Lopressor side effects »
How it works
PlendilLopressor
Plendil (Felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.Lopressor (Metoprolol Tartrate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
PlendilLopressor
Prescription only
Prescription only
Available as
PlendilLopressor
  • Extended release
  • Pill
Used for
PlendilLopressor
Risk factors for serious side effects
PlendilLopressor
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • Over age 65
  • History of heart failure
  • History of kidney disease
Detailed Plendil (Felodipine) risks & warnings »
  • Diabetes
    • Coronary artery disease
    • Heart failure
    • Major surgery requiring anesthesia
    • History of asthma
    Detailed Lopressor (Metoprolol Tartrate) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    PlendilLopressor
    • Plendil (Felodipine) can be taken without food or with a light low fat meal.
    • Take it with food.
    Upsides and benefits
    PlendilLopressor
    • Plendil (Felodipine) is a good option for people with high blood pressure.
    • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
    • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
    • A first-choice treatment for heart failure. May prevent long-term heart damage.
    • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
    Downsides and risks
    PlendilLopressor
    • Plendil (Felodipine) may not work as well as other calcium channel blockers.
    • It can lead to more swelling in your arms and legs when taken at higher doses.
    • You can't miss doses. Stopping Plendil (Felodipine) could cause a sudden spike in blood pressure.
    • Plendil (Felodipine) can't be crushed or cut into two.
    • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
    • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
    • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
    • Can hide symptoms of low blood sugar if you're diabetic.
    • You can't miss doses. Stopping Metoprolol tartrate suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    Tips from our pharmacists for people taking the medication
    PlendilLopressor
    • Can cause swelling in your legs or ankles.
    • Can also cause swelling in your gums.
    • Plendil (Felodipine) can be taken without food or with a light low fat meal.
    • Avoid grapefruit and grapefruit juice while taking Plendil (Felodipine).
    • You might feel lightheaded or dizzy when first starting Plendil (Felodipine).
    • Take it with food.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Can cause fatigue and headache.
    • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
    • Don't stop taking this medicine suddenly.
    • This is the immediate release version. It also comes as an extended release form: Toprol XL (metoprolol succinate).
    Learn more
    More about PlendilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Plendil (Felodipine)?
    Worth itNot sureNot worth it
    More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Lopressor (Metoprolol Tartrate)?
    Worth itNot sureNot worth it