Compare felodipine vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plendil
(felodipine)

Minipress
(prazosin)

Lowers blood pressure. Plendil (felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
Reviews & ratings
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Have you used Plendil (felodipine)?
Worth itNot sureNot worth it
Reviews for Prazosin
46%
-46% worse vs. felodipine
29%
-29% worse vs. felodipine
15%
+15% better vs. felodipine
Have you used Minipress (prazosin)?
Worth itNot sureNot worth it
Side effects
felodipinePrazosin
  • Headache 1%
  • Flushing 3%
  • Upset stomach 3%
  • Weakness 1%
  • Colds or flu 2%
  • Runny nose 2%
  • Sneezing 2%
  • Rash 1%
More felodipine side effects »
  • Dizziness 10%
  • Headache 8%
  • Drowsiness 8%
  • Lack of energy 7%
  • Weakness 7%
  • Heart pounding or racing sensation 5%
  • Nausea 5%
More Prazosin side effects »
How it works
felodipinePrazosin
Plendil (felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
felodipinePrazosin
Prescription onlyPrescription only
Available as
felodipinePrazosin
  • Extended release
  • Pill
Used for
felodipinePrazosin
Risk factors for serious side effects
felodipinePrazosin
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • History of heart failure
Detailed Plendil (felodipine) risks & warnings »
  • Age 65 years or older
Detailed Minipress (prazosin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
felodipinePrazosin
  • Plendil (felodipine) can be taken without food or with a light low fat meal.
  • Take with food or at bedtime to avoid side effects.
Sleep
felodipinePrazosin
No sleep related info.
  • Can cause drowsiness, headache, dizziness, and nausea.
Upsides and benefits
felodipinePrazosin
  • Plendil (felodipine) is a good option for people with high blood pressure.
  • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Makes urination easier in men with an enlarged prostate.
  • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
Downsides and risks
felodipinePrazosin
  • Plendil (felodipine) may not work as well as other calcium channel blockers.
  • It can lead to more swelling in your arms and legs when taken at higher doses.
  • You can't miss doses. Stopping Plendil (felodipine) could cause a sudden spike in blood pressure.
  • Plendil (felodipine) can't be crushed or cut into two.
  • Not the best medicine to lower blood pressure by itself.
  • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
  • Not preferred for people 65 years or older.
Tips from our pharmacists for people taking the medication
felodipinePrazosin
  • Can cause swelling in your legs or ankles.
  • Can also cause swelling in your gums.
  • Plendil (felodipine) can be taken without food or with a light low fat meal.
  • Avoid grapefruit and grapefruit juice while taking Plendil (felodipine).
  • You might feel lightheaded or dizzy when first starting Plendil (felodipine).
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause drowsiness, headache, dizziness, and nausea.
  • Take with food or at bedtime to avoid side effects.
  • If side effects don't go away, talk to your doctor about alternatives.
  • Recheck your blood pressure 1 week after starting this medicine.
Learn more
More about felodipineSide effectsAlternativesFDA package insert
Have you used Plendil (felodipine)?
Worth itNot sureNot worth it
More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Minipress (prazosin)?
Worth itNot sureNot worth it