Compare Plendil vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Plendil
(Felodipine)

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Lowers blood pressure. Plendil (Felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
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Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
Reviews for Zestoretic (Lisinopril / Hydrochlorothiazide)
51%
+1% vs. Plendil (Felodipine)
40%
10% vs. Plendil (Felodipine)
17%
+33% vs. Plendil (Felodipine)
294 reviews
Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
PlendilZestoretic
  • Swelling 14%
  • Flushing 6%
  • Headache 5%
  • Upset stomach 3%
  • Racing heart beat 2%
  • Colds or flu 2%
  • Dizziness 1%
  • Weakness 1%
  • Constipation 1%
  • Nausea 1%
More Plendil side effects »
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Muscle weakness 1%
  • Diarrhea 1%
More Zestoretic side effects »
How it works
PlendilZestoretic
Plendil (Felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
PlendilZestoretic
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
ACE inhibitor
Diuretic
Prescription only
Available as
PlendilZestoretic
  • Extended release
  • Pill
Used for (click to learn more)
PlendilZestoretic
Risk factors for serious side effects
PlendilZestoretic
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • History of heart failure
  • History of kidney disease
Detailed risks & warnings »
  • Women of childbearing age
  • African descent
  • People requiring high flux dialysis
  • History of kidney disease
  • Current kidney problems
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
PlendilZestoretic
  • Plendil (Felodipine) can be taken without food or with a light low fat meal.
No food related info.
Kidneys and liver
PlendilZestoretic
No kidneys and liver related info.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
Upsides and benefits
PlendilZestoretic
  • Plendil (Felodipine) is a good option for people with high blood pressure.
  • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
Downsides and risks
PlendilZestoretic
  • Plendil (Felodipine) may not work as well as other calcium channel blockers.
  • It can lead to more swelling in your arms and legs when taken at higher doses.
  • You can't miss doses. Stopping Plendil (Felodipine) could cause a sudden spike in blood pressure.
  • Plendil (Felodipine) can't be crushed or cut into two.
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
PlendilZestoretic
  • Can cause swelling in your legs or ankles.
  • Can also cause swelling in your gums.
  • Plendil (Felodipine) can be taken without food or with a light low fat meal.
  • Avoid grapefruit and grapefruit juice while taking Plendil (Felodipine).
  • You might feel lightheaded or dizzy when first starting Plendil (Felodipine).
  • Makes you urinate more often, so avoid taking it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
Learn more
More about PlendilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it
More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
Worth itNot sureNot worth it