Compare Pradaxa vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pradaxa
(dabigatran)

Xarelto
(rivaroxaban)

Prevents blood clots. Pradaxa (Dabigatran) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.Prevents blood clots. Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.
Reviews & ratings
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Have you used Pradaxa (dabigatran)?
Worth itNot sureNot worth it
Reviews for Xarelto
45%
+5% better vs. Pradaxa
45%
+22% better vs. Pradaxa
9%
+9% better vs. Pradaxa
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it
Side effects
PradaxaXarelto
  • GI side effect 35%
  • Any side effect 21%
  • Any bleed 20%
  • Dyspepsia 8%
  • Major gastrointestinal bleed 6%
  • GI bleed 3%
  • Major bleed 3%
  • Gastritis-like symptoms 3%
  • Gastrointestinal bleed 2%
  • Life-threatening bleed 2%
More Pradaxa side effects »
  • Major bleeding needing transfusion 4%
  • Bleeding in the stomach & intestines 2%
  • Complaints of bleeding 28%
  • Clinically relevant but not major bleeding 9%
  • Back pain 3%
  • Upper abdominal pain 2%
  • Joint arthritis 1%
  • Any bleeding event after hip or knee replacement surgery 6%
  • Any side effect causing stopping of Xarelto (rivaroxaban) 4%
  • Wound drainage 3%
More Xarelto side effects »
How it works
PradaxaXarelto
Pradaxa (Dabigatran) is an anticoagulant that stops the formation of blood clots.Xarelto (rivaroxaban) is an anticoagulant that stops blood clots from forming.
Type of medication
PradaxaXarelto
Prescription onlyPrescription only
Available as
PradaxaXarelto
  • Pill
  • Pill
Used for
PradaxaXarelto
Risk factors for serious side effects
PradaxaXarelto
  • Stopping Pradaxa (Dabigatran) too soon
  • Spinal tap
  • Anesthesia along the spine (epidural anesthesia)
  • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Drug interactions
Detailed Pradaxa (dabigatran) risks & warnings »
  • Stopping Xarelto (rivaroxaban) too soon
  • Artificial heart valve
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
Detailed Xarelto (rivaroxaban) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
PradaxaXarelto
No interactions related info.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Food
PradaxaXarelto
No food related info.
  • Like all blood thinners, it will take a little longer for your blood to clot if you start bleeding while you're taking Xarelto (rivaroxaban). Call your doctor if you notice bleeding that won't stop, a bruise that won't go away or gets worse, pink or brown urine, bright red or dark tarry stool, nose bleeds, or if you start coughing up blood.
Kidneys and liver
PradaxaXarelto
No kidneys and liver related info.
  • Xarelto (rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to avoid other side effects.
Upsides and benefits
PradaxaXarelto
  • Clinical studies have shown that the risk of stroke and blood clots is lower than with warfarin, another popular "blood thinner" (anticoagulant).
  • Doesn't require regular blood tests or frequent dose changes.
  • In studies comparing Pradaxa (Dabigatran) to other "blood thinners", it worked just as well in preventing strokes and was better in lowering the risk of bleeding.
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Downsides and risks
PradaxaXarelto
  • Not available as generic.
  • There are no antidotes to stop bleeding caused by taking too much Pradaxa (Dabigatran).
  • Can't take during pregnancy.
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
Tips from our pharmacists for people taking the medication
PradaxaXarelto
  • Pradaxa (Dabigatran) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
  • When taking Pradaxa (Dabigatran), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • Take this exactly as your doctor or pharmacist tells you to.
  • Take with a full glass of water. Swallow the capsule whole. Don't chew, break, or open the capsule.
  • Xarelto (rivaroxaban) prevents blood from clotting, so it's important not to miss a dose. If you miss your daily dose, take it as soon as you remember that day. Just don't take two doses close to each other.
  • If you completely forget to take a dose, call your doctor right away.
  • When taking Xarelto (rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • You can crush the pills and mix it with a spoonful of applesauce, but make sure to eat some food and drink a glass of water right away.
Learn more
More about PradaxaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pradaxa (dabigatran)?
Worth itNot sureNot worth it
More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it