Compare Pradaxa vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pradaxa
(Dabigatran)

Xarelto
(Rivaroxaban)

Prevents blood clots. Pradaxa (Dabigatran) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.Prevents blood clots. Xarelto (Rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.
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Reviews & ratings
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Side effects
PradaxaXarelto

The Pradaxa FDA package insert doesn’t have numbers about how common side effects are.

More about Pradaxa side effects »
  • Back pain 3%
More Xarelto side effects »
How it works
PradaxaXarelto
Pradaxa (Dabigatran) is an anticoagulant that stops the formation of blood clots.Xarelto (Rivaroxaban) is an anticoagulant that stops the formation of blood clots.
Type of medication
PradaxaXarelto
Anticoagulant
Thrombin inhibitor
Prescription only
Anticoagulant
Factor Xa inhibitor
Prescription only
Available as
PradaxaXarelto
  • Pill
  • Pill
Used for (click to learn more)
PradaxaXarelto
Risk factors for serious side effects
PradaxaXarelto
  • Stopping Pradaxa (Dabigatran) too soon
  • Spinal tap
  • Anesthesia along the spine (epidural anesthesia)
  • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Drug interactions
  • Taking with NSAIDs, aspirin, or other blood-thinning medicines
    • Artificial heart valve
    Detailed Pradaxa (Dabigatran) risks & warnings »
    • Stopping Xarelto (Rivaroxaban) too soon
    • Artificial heart valve
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
    • History of bleeding problems
    • Severe high blood pressure
    • Age 65 or older
    • Drug interactions
    • Taking NSAIDs, aspirin, or other blood-thinning medicines
    • Current kidney problems
    • Current liver problems
    Detailed Xarelto (Rivaroxaban) risks & warnings »
    Pregnancy category
    PradaxaXarelto
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
    • Take Xarelto (Rivaroxaban) with food and a full glass of water.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • Xarelto (Rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to prevent increased risk for side effects.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    PradaxaXarelto
    • Clinical studies have shown that the risk of stroke and blood clots is lower than with warfarin, another popular "blood thinner" (anticoagulant).
    • Doesn't require regular blood tests or frequent dose changes.
    • In studies comparing Pradaxa (Dabigatran) to other "blood thinners", it worked just as well in preventing strokes and was better in lowering the risk of bleeding.
    • Studies have shown that Xarelto (Rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and reducing bleeding.
    • Xarelto (Rivaroxaban) doesn't require regular blood testing or frequent dose adjustments.
    • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
    Downsides and risks
    PradaxaXarelto
    • Not available as generic.
    • There are no antidotes to stop bleeding caused by taking too much Pradaxa (Dabigatran).
    • Can't take during pregnancy.
    • Xarelto (Rivaroxaban) can increase your risk of bleeding. Call your doctor right away if there is blood in your phlegm, urine, or stool (look for black, tarry stools).
    • Xarelto (Rivaroxaban) isn't available as a generic medication.
    • There are no antidotes to stop bleeding caused by taking too much Xarelto (Rivaroxaban).
    • Can't take during pregnancy.
    Tips from our pharmacists for people taking the medication
    PradaxaXarelto
    • Pradaxa (Dabigatran) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
    • When taking Pradaxa (Dabigatran), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
    • Take this exactly as your doctor or pharmacist tells you to.
    • Take with a full glass of water. Swallow the capsule whole. Don't chew, break, or open the capsule.
    • Xarelto (Rivaroxaban) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
    • When taking Xarelto (Rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
    • Take Xarelto (Rivaroxaban) with food and a full glass of water.
    • You can crush the tablets and mix with applesauce.
    Learn more
    More about PradaxaSide effectsReviews & ratingsAlternativesFDA package insert
    More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert