Compare Prandin vs. Invokana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prandin (repaglinide)

Prescription only

Invokana (canagliflozin)

Prescription only
Lowers blood sugar.

Prandin (repaglinide) works quickly to lower blood sugar, especially during mealtimes. However, it can cause hypoglycemia (low blood sugar) if you are not consistent with your diet and exercise schedule.

Lowers blood sugar.

Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.

5.5/ 7 average rating with 27 reviewsforInvokana
Upsides
  • Quickly and effectively lowers blood sugar during meal times.
  • Less likely to cause hypoglycemia (low blood sugar) than Starlix (nateglinide).
  • Good first-choice if you cannot tolerate metformin or add-on therapy if your blood sugars are not controlled on metformin alone.
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
Downsides
  • May cause some weight gain.
  • May cause hypoglycemia (low blood sugar).
  • Can frequently interfere with how other medicines work.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$36.24
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$444.76
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Reviews
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27 
67%
think this treatment is worth it
56%
think this treatment works well
19%
think this treatment is a hassle

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Side effects
10possible side effects
  • Low blood sugar
    31%
  • Headache
    11%
  • Sinusitis
    6%
  • Joint pain
    6%
  • Nausea
    5%
  • Diarrhea
    5%
  • Back pain
    5%
  • Swelling in arms and legs
    5%
  • Heart failure
    4%
  • Rhinitis
    3%
See more detailed side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
Risks and warnings
  • Low blood sugar (hypoglycemia)

    Alcoholism

    ...and 6 more risk factors

  • Heart damage

    use with NPH-insulin

See more detailed risks and warnings
  • Increased risk of leg and foot amputations

    History of amputations 

    ...and 3 more risk factors

  • Kidney damage and low blood pressure

    History of kidney damage

    ...and 3 more risk factors

  • Low blood sugar (hypoglycemia)

    Taking medicines for diabetes

  • Increased acid and ketones in the blood

    Long periods of fasting

    ...and 3 more risk factors

See more detailed risks and warnings