Compare Prandin vs. Invokana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prandin
(repaglinide)

Invokana
(canagliflozin)

Lowers blood sugar. Prandin (repaglinide) works quickly to lower blood sugar, especially during mealtimes. However, it can cause hypoglycemia (low blood sugar) if you are not consistent with your diet and exercise schedule.Lowers blood sugar. Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.
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Coupons for Invokana
Best available price for 30 (300mg) tablets of invokana
Reviews & ratings
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Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it
Reviews for Invokana
67%
-67% worse vs. Prandin
56%
-56% worse vs. Prandin
19%
+19% better vs. Prandin
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
Side effects
PrandinInvokana
  • Common cold 8%
  • Low blood sugar 24%
  • Headache 1%
  • Joint pain 3%
  • Sinus inflammation 4%
  • Diarrhea 3%
  • Back pain 1%
  • Swelling in arms and legs 5%
  • Heart failure 4%
More Prandin side effects »
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokana side effects »
How it works
PrandinInvokana
Prandin (repaglinide) stimulates your body to produce more insulin.Invokana (canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.
Type of medication
PrandinInvokana
Prescription onlyPrescription only
Available as
PrandinInvokana
  • Pill
  • Pill
Used for
PrandinInvokana
Risk factors for serious side effects
PrandinInvokana
  • Alcoholism
  • Changes in meal pattern
  • Changes in exercise
  • Insulin
  • Other antidiabetic medications
Detailed Prandin (repaglinide) risks & warnings »
  • History of amputations 
  • Peripheral vascular disease (narrowed blood vessels)
  • Nerve problems
  • Diabetic foot ulcers 
  • History of kidney damage
Detailed Invokana (canagliflozin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
PrandinInvokana
No alcohol related info.
  • Avoid if you are a heavy drinker of alcohol.
Food
PrandinInvokana
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Quickly and effectively lowers blood sugar during meal times.
  • Take once daily before your first meal of the day.
  • You only have to take Invokana (canagliflozin) once a day before meals.
Kidneys and liver
PrandinInvokana
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
  • Not for people with severe kidney problems.
Pain
PrandinInvokana
No pain related info.
  • Rarely, Invokana (canagliflozin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Invokana (canagliflozin) can also lower your blood pressure since it makes you urinate more. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokana (canagliflozin). Make sure to stay hydrated to prevent low blood pressure and kidney problems.
Weight
PrandinInvokana
  • May cause some weight gain.
No weight related info.
Upsides and benefits
PrandinInvokana
  • Quickly and effectively lowers blood sugar during meal times.
  • Less likely to cause hypoglycemia (low blood sugar) than Starlix (nateglinide).
  • Good first-choice if you cannot tolerate metformin or add-on therapy if your blood sugars are not controlled on metformin alone.
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
Downsides and risks
PrandinInvokana
  • May cause some weight gain.
  • May cause hypoglycemia (low blood sugar).
  • Can frequently interfere with how other medicines work.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
Tips from our pharmacists for people taking the medication
PrandinInvokana
  • Works quickly to lower blood sugar so should be taken 15 to 30 minutes before a meal.
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Maintain a regular diet and exercise schedule while on this medicine to prevent fluctuations in your blood sugar.
  • Take once daily before your first meal of the day.
  • Invokana (canagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Can cause low blood sugar, so make sure to check your blood sugar if you don't feel well.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Invokana (canagliflozin).
Learn more
More about PrandinSide effectsAlternativesFDA package insert
Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it
More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it