Compare Prandin vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prandin
(repaglinide)

Januvia
(sitagliptin)

Lowers blood sugar. Prandin (repaglinide) works quickly to lower blood sugar, especially during mealtimes. However, it can cause hypoglycemia (low blood sugar) if you are not consistent with your diet and exercise schedule.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.
Reviews & ratings
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Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
-44% worse vs. Prandin
34%
-34% worse vs. Prandin
17%
+17% better vs. Prandin
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Side effects
PrandinJanuvia
  • Common cold 8%
  • Low blood sugar 24%
  • Headache 1%
  • Joint pain 3%
  • Sinusitis 4%
  • Diarrhea 3%
  • Back pain 1%
  • Swelling in arms and legs 5%
  • Heart failure 4%
More Prandin side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
How it works
PrandinJanuvia
Prandin (repaglinide) stimulates your body to produce more insulin.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.
Type of medication
PrandinJanuvia
Prescription onlyPrescription only
Available as
PrandinJanuvia
  • Pill
  • Pill
Used for
PrandinJanuvia
Risk factors for serious side effects
PrandinJanuvia
  • Alcoholism
  • Changes in meal pattern
  • Changes in exercise
  • Insulin
  • Other antidiabetic medications
Detailed Prandin (repaglinide) risks & warnings »
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
PrandinJanuvia
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Quickly and effectively lowers blood sugar during meal times.
  • Take once a day in the morning with or without food.
Kidneys and liver
PrandinJanuvia
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
Pain
PrandinJanuvia
No pain related info.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
Weight
PrandinJanuvia
  • May cause some weight gain.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Upsides and benefits
PrandinJanuvia
  • Quickly and effectively lowers blood sugar during meal times.
  • Less likely to cause hypoglycemia (low blood sugar) than Starlix (nateglinide).
  • Good first-choice if you cannot tolerate metformin or add-on therapy if your blood sugars are not controlled on metformin alone.
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Downsides and risks
PrandinJanuvia
  • May cause some weight gain.
  • May cause hypoglycemia (low blood sugar).
  • Can frequently interfere with how other medicines work.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
Tips from our pharmacists for people taking the medication
PrandinJanuvia
  • Works quickly to lower blood sugar so should be taken 15 to 30 minutes before a meal.
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Maintain a regular diet and exercise schedule while on this medicine to prevent fluctuations in your blood sugar.
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
Learn more
More about PrandinSide effectsAlternativesFDA package insert
Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it