Compare pravastatin vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pravachol
(pravastatin)

Vytorin
(ezetimibe / simvastatin)

Lowers cholesterol. Pravachol (pravastatin) can improve cholesterol, but it's not as strong as other statin medicines. It does cause fewer side effects and is safer for your kidneys and liver.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
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Prices and coupon for 30 (40mg) tablets of pravastatin
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Prices and coupon for 30 (10mg/40mg) tablets of ezetimibe / simvastatin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.76pravastatin
Reviews for Pravachol (pravastatin)
54%
of people (All ages) say Pravachol (pravastatin) is worth it
44%
say it works well
19%
say it's a big hassle
426 reviews
Have you used Pravachol (pravastatin)?
Worth itNot sureNot worth it
Reviews for Vytorin (ezetimibe / simvastatin)
53%
-1% worse vs. Pravachol (pravastatin)
36%
-8% worse vs. Pravachol (pravastatin)
19%
Same vs. Pravachol (pravastatin)
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
Side effects
pravastatinVytorin
  • Upper respiratory infection 4%
  • Diarrhea 3%
  • Headache 2%
  • Chest pain 2%
  • Sore throat 2%
  • Rash 2%
  • Muscle pain 2%
More pravastatin side effects »
  • Headache 1%
  • Any side effect 3%
  • Muscle pain 4%
  • Ear, nose, or throat infection 4%
  • Increased alt 4%
  • Diarrhea 3%
  • Flu 1%
  • Pain in extremity 1%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
How it works
pravastatinVytorin
Pravachol (pravastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
pravastatinVytorin
Prescription only
Prescription only
Available as
pravastatinVytorin
  • Pill
  • Pill
Used for
pravastatinVytorin
Risk factors for serious side effects
pravastatinVytorin
  • Kidney disease
  • An underactive thyroid
  • Over age 65
  • Female gender
  • Taking other medicines to lower your cholesterol
  • Heavy alcohol use
  • History of chronic liver disease
  • Pregnancy
  • Breast feeding
  • Spironolactone use
  • Cimetidine use
  • Ketoconazole use
Detailed Pravachol (pravastatin) risks & warnings »
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
      • Pregnancy
      Detailed Vytorin (ezetimibe / simvastatin) risks & warnings »
      Pregnancy

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      Kidneys and liver
      pravastatinVytorin
      • Pravachol (pravastatin) is less likely to cause muscle and kidney damage than other statin medicines.
      • If you have liver problems, Pravachol (pravastatin) is the safest statin to use.
      • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
      Upsides and benefits
      pravastatinVytorin
      • Compared to other statins, Pravachol (pravastatin) has fewer interactions with medicines.
      • Pravachol (pravastatin) is less likely to cause muscle and kidney damage than other statin medicines.
      • If you have liver problems, Pravachol (pravastatin) is the safest statin to use.
      • It's available as a generic.
      • A 2-in-1 cholesterol-lowering combination medicine.
      • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      Downsides and risks
      pravastatinVytorin
      • Pravachol (pravastatin) isn't as strong as other statins in lowering your cholesterol.
      • You'll still need to eat a low fat diet and exercise regularly to get the full benefit of Pravachol (pravastatin).
      • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
      • There's no generic available, so it can be expensive.
      Tips from our pharmacists for people taking the medication
      pravastatinVytorin
      • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
      • Most people reach their target cholesterol levels in 4 to 6 weeks.
      • Don't eat grapefruit and drink grapefruit juice while taking this medicine.
      • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
      • Also let your doctor know if you notice dark urine or yellowing of your eyes or skin.
      • You'll need to stop taking Pravachol (pravastatin) if you get pregnant.
      • Take it in the evening.
      • Avoid grapefruit and grapefruit juice while taking this medicine.
      • Can cause headaches or diarrhea.
      • Call your doctor if you develop muscle pain.
      • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
      Learn more
      More about pravastatinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Pravachol (pravastatin)?
      Worth itNot sureNot worth it
      More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Vytorin (ezetimibe / simvastatin)?
      Worth itNot sureNot worth it