Compare pravastatin vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pravachol
(pravastatin)

Zetia
(ezetimibe)

Lowers cholesterol. Pravachol (pravastatin) can improve cholesterol, but it's not as strong as other statin medicines. It does cause fewer side effects and is safer for your kidneys and liver.Lowers cholesterol. Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.
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Prices and coupon for 30 (40mg) tablets of pravastatin
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Prices and coupon for 30 (10mg) tablets of ezetimibe
Reviews & ratings
Filter group. All currently selected
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4.76pravastatin
Reviews for Pravachol (pravastatin)
54%
of people (All ages) say Pravachol (pravastatin) is worth it
44%
say it works well
19%
say it's a big hassle
426 reviews
Have you used Pravachol (pravastatin)?
Worth itNot sureNot worth it
Reviews for Zetia (ezetimibe)
42%
-12% worse vs. Pravachol (pravastatin)
34%
-10% worse vs. Pravachol (pravastatin)
21%
-2% worse vs. Pravachol (pravastatin)
128 reviews
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
Side effects
pravastatinZetia
  • Upper respiratory infection 4%
  • Diarrhea 3%
  • Headache 2%
  • Chest pain 2%
  • Sore throat 2%
  • Rash 2%
  • Muscle pain 2%
More pravastatin side effects »
  • Common cold 1%
  • Sore throat 4%
  • Sinus infection 1%
  • Abnormal liver tests 3%
  • Joint pain 1%
  • Pain in arms and legs 1%
  • Muscle pain 3%
More Zetia side effects »
How it works
pravastatinZetia
Pravachol (pravastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Zetia (ezetimibe) is a cholesterol-lowering medicine. It stops your body from absorbing cholesterol in food and helps process other forms of cholesterol.
Type of medication
pravastatinZetia
Prescription only
Prescription only
Available as
pravastatinZetia
  • Pill
  • Pill
Used for
pravastatinZetia
Risk factors for serious side effects
pravastatinZetia
  • Kidney disease
  • An underactive thyroid
  • Over age 65
  • Female gender
  • Taking other medicines to lower your cholesterol
  • Heavy alcohol use
  • History of chronic liver disease
  • Pregnancy
  • Breast feeding
  • Spironolactone use
  • Cimetidine use
  • Ketoconazole use
Detailed Pravachol (pravastatin) risks & warnings »
    • Taking Zetia (ezetimibe) with statins
    • Past history of liver disease
    • Taking Zetia (ezetimibe) with statins
    Detailed Zetia (ezetimibe) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    pravastatinZetia
    • Pravachol (pravastatin) is less likely to cause muscle and kidney damage than other statin medicines.
    • If you have liver problems, Pravachol (pravastatin) is the safest statin to use.
    • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
    Pain
    pravastatinZetia
    No pain related info.
    • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
    Upsides and benefits
    pravastatinZetia
    • Compared to other statins, Pravachol (pravastatin) has fewer interactions with medicines.
    • Pravachol (pravastatin) is less likely to cause muscle and kidney damage than other statin medicines.
    • If you have liver problems, Pravachol (pravastatin) is the safest statin to use.
    • It's available as a generic.
    • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
    • Can be used with other medicines to improve cholesterol.
    • Available in a combination pill with simvastatin.
    • Available as a generic.
    Downsides and risks
    pravastatinZetia
    • Pravachol (pravastatin) isn't as strong as other statins in lowering your cholesterol.
    • You'll still need to eat a low fat diet and exercise regularly to get the full benefit of Pravachol (pravastatin).
    • Doesn't lower triglycerides (fats).
    • Hasn't been shown to lower the risk of heart attacks or heart disease.
    • By itself, it isn't as effective as statins for improving cholesterol.
    Tips from our pharmacists for people taking the medication
    pravastatinZetia
    • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
    • Most people reach their target cholesterol levels in 4 to 6 weeks.
    • Don't eat grapefruit and drink grapefruit juice while taking this medicine.
    • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
    • Also let your doctor know if you notice dark urine or yellowing of your eyes or skin.
    • You'll need to stop taking Pravachol (pravastatin) if you get pregnant.
    • Lowers bad cholesterol and raises good cholesterol.
    • Tell your doctor if you develop bone or muscle pain.
    • Can be used with other medications to lower cholesterol.
    • Good alternative to statins if you can't tolerate statins or are unable to control cholesterol with statins alone.
    • Can cause diarrhea or increase your chance of getting colds.
    Learn more
    More about pravastatinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Pravachol (pravastatin)?
    Worth itNot sureNot worth it
    More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zetia (ezetimibe)?
    Worth itNot sureNot worth it