Compare Prednisolone vs. dexamethasone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pred Forte (Prednisolone)

Prescription only

Decadron (dexamethasone)

Prescription only
Treats eye redness and swelling.

Pred Forte (Prednisolone) is strong medicine for eye redness and swelling without exposing the rest of your body to the steroid medicine.

Calms down your immune system.

Decadron (dexamethasone) is a long-acting oral corticosteroid that is very effective in treating allergic reactions and immune conditions, however, if you're taking Decadron (dexamethasone) for a long time, there can be serious side effects.

Upsides
  • Decreases swelling and redness in your eyes.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
  • Effective in treating many conditions.
  • Can improve energy and appetite.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
  • Has long-term benefit in calming down the immune system and keeping it from causing your body harm, such as in autoimmune conditions.
  • Available in generic form.
Downsides
  • Available only as a prescription medication.
  • You need good hand-eye coordination to get the eye drops into your eyes.
  • Can cause or worsen certain eye conditions.
  • Many side effects, particularly with long term use.
  • Side effects include mood changes, trouble sleeping and increase in blood pressure and blood sugar at higher doses.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • If you've been using corticosteroids for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly.
  • Limited studies conducted with use of steroids during pregnancy or breastfeeding - potential harm to unborn baby.
Used for
  • Allergies
  • Skin Conditions
  • Endocrine Conditions
  • Eye Conditions
  • Stomach Conditions
  • Respiratory disorder
  • Multiple sclerosis flare
  • Hematologic Conditions
  • Cancer
  • Autoimmune and Rheumatic Conditions
Dosage forms
  • Eye drops
  • Pill
  • Liquid
Price
Lowest price near you
$8.23
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Lowest price near you
$9.85
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Reviews
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Side effects
The Pred Forte (Prednisolone) FDA package insert doesn’t have numbers about how common side effects are.
The Decadron (dexamethasone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Cataracts

    Long-term use

  • Cornea hole

    Long-term use

  • Glaucoma

    Long-term use

    ...and 1 more risk factors

  • Infections in your eyes

    Long-term use

See more detailed risks and warnings
  • Lowered adrenal function

    Lowering dose or stopping too quickly especially after long-term treatment

    ...and 1 more risk factors

  • Increased risk for infections

    Taking other immunosuppressants

    ...and 4 more risk factors

  • Changes in heart and kidney function

    Recent heart attack

  • Stomach and intestinal problems

    History of stomach bleeding

    ...and 3 more risk factors

  • Bone effects

    Dose of Decadron (dexamethasone)

    ...and 1 more risk factors

See more detailed risks and warnings