Compare Prednisolone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pred Forte


Treats eye redness and swelling. Pred Forte (Prednisolone) is strong medicine for eye redness and swelling without exposing the rest of your body to the steroid medicine.Calms down your immune system. Medrol (Methylprednisolone) is corticosteroid available in many forms (oral, injectable) that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.
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Reviews & ratings
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Reviews for Medrol (Methylprednisolone)
43% vs. Pred Forte (Prednisolone)
+51% vs. Pred Forte (Prednisolone)
23% vs. Pred Forte (Prednisolone)
Side effects

The Prednisolone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisolone side effects »

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »
How it works
Pred Forte (Prednisolone) is a steroid that lowers your immune response to allergens and reduces eye redness and swelling.Medrol (Methylprednisolone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.
Type of medication
CorticosteroidPrescription only
Anti-inflammatory, Immunosuppressant
Prescription only
Available as
  • Eye drops
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • Long-term use
  • Long-term use
  • Long-term use
  • History of glaucoma
  • Long-term use
Detailed Pred Forte (Prednisolone) risks & warnings »
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Duration of treatment
    • History of psychiatric conditions
    • Dose of Medrol (Methylprednisolone)
    • Duration of treatment
    • Women of childbearing age
    • History of stomach bleeding
    • Active or history of stomach or duodenal ulcers
    • Ulcerative colitis
    • Taking Medrol (Methylprednisolone) with other medicine that can cause stomach problems
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
    Detailed Medrol (Methylprednisolone) risks & warnings »
    Pregnancy category
    No specific alcohol-related info.
    • Taking Medrol (Methylprednisolone) increases the risk of injury to the lining of your stomach and intestine including irritation, tears/holes and ulcers. You should avoid alcohol/alcoholic beverages because it can worsen stomach irritation. Tell your doctor or get medical care right away if you have stomach pain, notice blood or dark colored stools when you go to the bathroom.
    No specific food-related info.
    • Take with food to decrease stomach upset.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.
    • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
    • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
    • Like most corticosteroid medicines, Medrol (Methylprednisolone) may cause changes in your mood or behavior. Tell your doctor right away if you become depressed, have mood swings, trouble sleeping, irritability or anxiety, hyperactivity, delusions or hallucinations while taking this medicine. If you need to make any changes or slowly taper your dose, talk to your doctor first.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • Decreases swelling and redness in your eyes.
    • Doesn't cause the same types of side effects that oral forms of steroids do.
    • Steroid magic, can help you feel better, have more energy and get more appetite.
    • Useful in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
    • Useful in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
    • Available in many different forms, including injection, that will expose the rest of your body less of the medicine.
    Downsides and risks
    • Available only as a prescription medication.
    • You need good hand-eye coordination to get the eye drops into your eyes.
    • Can cause or worsen certain eye conditions.
    • Lots of side effects, especially with long term use.
    • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
    • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
    • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Medrol.
    • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
    Tips from our pharmacists for people taking the medication
    • Shake the eye drops well before using.
    • Press your finger gently on the inner corner of your eye after the drops are in to keep them there.
    • Wait 1 minute between each drop if you're giving yourself more than 1 drop.
    • If you have other eye drops, wait 5 minutes in between different sets of eye drops.
    • If your symptoms don't get better after 2 days, you may need to try a different medicine.
    • Let your doctor know if you have eye pain, pressure, infections, or changes in eye sight.
    • The dose and duration on how long you need the medicine depends on your condition and response.
    • Take it exactly as your doctor prescribed.
    • Take with food to decrease stomach upset.
    • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
    • Can cause changes in mood, blood pressure, blood sugar, and water retention.
    • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
    • A taper is often needed to stop the medicine, especially if you've been on it for more than 1 week.
    Learn more
    More about PrednisoloneSide effectsReviews & ratingsAlternativesFDA package insert
    More about MedrolSide effectsReviews & ratingsAlternativesFDA package insert