Compare Prednisolone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pred Forte
(prednisolone)

Medrol
(methylprednisolone)

Treats eye redness and swelling. Pred Forte (Prednisolone) is strong medicine for eye redness and swelling without exposing the rest of your body to the steroid medicine.Calms down your immune system. Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.
Reviews & ratings
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Have you used Pred Forte (prednisolone)?
Worth itNot sureNot worth it
Reviews for Medrol
59%
+41% better vs. Prednisolone
53%
-53% worse vs. Prednisolone
23%
+23% better vs. Prednisolone
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it
Side effects
PrednisoloneMedrol

The Prednisolone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisolone side effects »

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »
How it works
PrednisoloneMedrol
Pred Forte (Prednisolone) is a steroid that lowers your immune response to allergens and reduces eye redness and swelling.Medrol (methylprednisolone) is a corticosteroid that is similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.
Type of medication
PrednisoloneMedrol
Prescription onlyPrescription only
Available as
PrednisoloneMedrol
  • Eye drops
  • Pill
  • Injection
Used for
PrednisoloneMedrol
Risk factors for serious side effects
PrednisoloneMedrol
  • Long-term use
  • History of glaucoma
Detailed Pred Forte (prednisolone) risks & warnings »
  • Taking high doses of Medrol (methylprednisolone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Medrol (methylprednisolone) for a long time
Detailed Medrol (methylprednisolone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
PrednisoloneMedrol
No food related info.
  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
Kidneys and liver
PrednisoloneMedrol
No kidneys and liver related info.
  • Medrol (methylprednisolone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
Pain
PrednisoloneMedrol
  • Let your doctor know if you have eye pain, pressure, infections, or changes in eye sight.
No pain related info.
Upsides and benefits
PrednisoloneMedrol
  • Decreases swelling and redness in your eyes.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
Downsides and risks
PrednisoloneMedrol
  • Available only as a prescription medication.
  • You need good hand-eye coordination to get the eye drops into your eyes.
  • Can cause or worsen certain eye conditions.
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
Tips from our pharmacists for people taking the medication
PrednisoloneMedrol
  • Shake the eye drops well before using.
  • Press your finger gently on the inner corner of your eye after the drops are in to keep them there.
  • Wait 1 minute between each drop if you're giving yourself more than 1 drop.
  • If you have other eye drops, wait 5 minutes in between different sets of eye drops.
  • If your symptoms don't get better after 2 days, you may need to try a different medicine.
  • Let your doctor know if you have eye pain, pressure, infections, or changes in eye sight.
  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Medrol (methylprednisolone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Medrol (methylprednisolone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Medrol (methylprednisolone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • While you are on this medicine, don't get any live vaccines, unless approved by your doctor.
  • Medrol (methylprednisolone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
Learn more
More about PrednisoloneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pred Forte (prednisolone)?
Worth itNot sureNot worth it
More about MedrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it