Compare prednisone vs. Allopurinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Rayos
(prednisone)

Zyloprim
(allopurinol)

Calms down your immune system. Rayos (prednisone) is effective for controlling allergic reactions and conditions involving the immune system. It can quickly make you feel better, but Rayos (prednisone) can cause serious complications and side effects if taken for a long time.Lowers uric acid levels in blood, and prevents gout flare-ups. Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.8prednisone
Reviews for prednisone
59%
of people (All ages) say prednisone is worth it
45%
say it works well
20%
say it's a big hassle
540 reviews
Have you used Rayos (prednisone)?
Worth itNot sureNot worth it
Reviews for Allopurinol
71%
-12% worse vs. prednisone
52%
-7% worse vs. prednisone
5%
-15% worse vs. prednisone
Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it
Side effects
prednisoneAllopurinol

The prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about prednisone side effects »

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
How it works
prednisoneAllopurinol
Rayos (prednisone) is a corticosteroid similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.Zyloprim (allopurinol) is a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which can stop gout attacks and kidney stones.
Type of medication
prednisoneAllopurinol
Prescription onlyPrescription only
Available as
prednisoneAllopurinol
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Injection
Used for
prednisoneAllopurinol
Risk factors for serious side effects
prednisoneAllopurinol
  • Taking high doses of Rayos (prednisone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Rayos (prednisone) for a long time
Detailed Rayos (prednisone) risks & warnings »
  • History of kidney stones
  • Taking other medications that also cause sleepiness
  • Recreational drug use
  • Excessive alcohol use
  • Elderly
Detailed Zyloprim (allopurinol) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
prednisoneAllopurinol
  • Taking Rayos (prednisone) increases the risk of injury to your stomach. You should avoid drinking alcohol while taking this medicine because it can worsen stomach irritation. Tell your doctor right away if you experience stomach pain that does not go away or you get bloody/dark stools.
No alcohol related info.
Food
prednisoneAllopurinol
  • Take Rayos (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Take with food or milk to prevent an upset stomach.
Kidneys and liver
prednisoneAllopurinol
  • Rayos (prednisone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
Sleep
prednisoneAllopurinol
No sleep related info.
  • Taking Zyloprim (allopurinol) can make you feel sleepy or dizzy, especially if you're taking other medicines that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you. Get up very slowly from a seated or lying down position.
Upsides and benefits
prednisoneAllopurinol
  • Rayos (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Rayos (prednisone) is available in a generic form.
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
Downsides and risks
prednisoneAllopurinol
  • Rayos (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Rayos (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Rayos (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
Tips from our pharmacists for people taking the medication
prednisoneAllopurinol
  • Take Rayos (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Rayos (prednisone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Rayos (prednisone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Rayos (prednisone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • Rayos (prednisone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
  • Drink plenty of water while taking Zyloprim (allopurinol).
  • Take with food or milk to prevent an upset stomach.
  • It takes at least 2 to 6 weeks to experience the full benefit of this medicine.
  • Your doctor can run blood tests to make sure the medication is working as it should.
  • During the first few weeks of starting this, you may need to be on a second anti-gout medicine to prevent flare-ups because Zyloprim (allopurinol) can cause gout attacks when you first start it.
  • If you're taking this because you have cancer, your doctor might have to change the doses of some of your chemotherapy drugs.
Learn more
More about prednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Rayos (prednisone)?
Worth itNot sureNot worth it
More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it