Compare Prednisone vs. Fludrocortisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Calms down your immune system. Deltasone (Prednisone) is a common oral corticosteroid that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.Coming soon.
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Reviews & ratings
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Reviews for Deltasone (Prednisone)
of people (All ages) say Deltasone (Prednisone) is worth it
say it works well
say it's a big hassle
529 reviews
Have you used Deltasone (Prednisone)?
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Have you used Fludrocortisone?
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Side effects

The Prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisone side effects »

We haven’t found good data for Fludrocortisone side effects.

FDA side effect reports for Fludrocortisone »
How it works
Deltasone (Prednisone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Coming soon.
Type of medication
Anti-inflammatory, Immunosuppressant
Prescription only
Coming soon.
Available as
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
  • Addison's disease - Adrenal insufficiency Adrenogenital disorder
Risk factors for serious side effects
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
  • History of bacterial or viral conditions
  • Duration of treatment
    • History of psychiatric conditions
    • Dose of Deltasone (Prednisone)
    • Duration of treatment
    • Women of childbearing age
    • History of stomach bleeding
    • Active or history of stomach or duodenal ulcers
    • Ulcerative colitis
    • Taking Deltasone (Prednisone) with other medicine that can cause stomach problems
    Detailed Deltasone (Prednisone) risks & warnings »
    Coming soon.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    • Take with food to decrease stomach upset.
    No food related info.
    Kidneys and liver
    • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Deltasone (Prednisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Deltasone (Prednisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
    No kidneys and liver related info.
    Upsides and benefits
    • Steroid magic, can help you feel better, have more energy and get more appetite.
    • Useful for many conditions.
    • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
    • Long-term use in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
    Coming soon
    Downsides and risks
    • Lots of side effects, especially with long term use.
    • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
    • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
    • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Prednisone.
    • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
    • Only available as an oral medicine so the rest of your body will be exposed to the medicine.
    Coming soon
    Tips from our pharmacists for people taking the medication
    • The dose and duration on how long you need the medicine depends on your condition and response.
    • Take it exactly as your doctor prescribed.
    • Take with food to decrease stomach upset.
    • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
    • Can cause changes in mood, blood pressure, blood sugar, and water retention.
    • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
    • A taper is is often needed to stop the medicine, especially if you've been on it for more than 1 week.
    Coming soon
    Learn more
    More about PrednisoneSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Deltasone (Prednisone)?
    Worth itNot sureNot worth it
    More about FludrocortisoneSide effectsFDA package insert
    Have you used Fludrocortisone?
    Worth itNot sureNot worth it