Compare prednisone vs. fludrocortisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Rayos
(prednisone)

fludrocortisone

Calms down your immune system. Rayos (prednisone) is effective for controlling allergic reactions and conditions involving the immune system. It can quickly make you feel better, but Rayos (prednisone) can cause serious complications and side effects if taken for a long time.Treats electrolyte imbalance. Fludrocortisone is one of the first choices used in Addison's disease to help maintain your electrolytes, but there are side effects.
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Reviews & ratings
Filter group. All currently selected
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4.8prednisone
Reviews for prednisone
59%
of people (All ages) say prednisone is worth it
45%
say it works well
20%
say it's a big hassle
540 reviews
Have you used Rayos (prednisone)?
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Have you used Fludrocortisone?
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Side effects
prednisonefludrocortisone

The prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about prednisone side effects »

The fludrocortisone FDA package insert doesn’t have numbers about how common side effects are.

More about fludrocortisone side effects »
How it works
prednisonefludrocortisone
Rayos (prednisone) is a corticosteroid similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.Fludrocortisone is a corticosteroid that is similar to what your body naturally makes. It is primarily used to maintain the sodium, potassium, and water balance in your body.
Type of medication
prednisonefludrocortisone
Prescription onlyPrescription only
Available as
prednisonefludrocortisone
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
Used for
prednisonefludrocortisone
  • Addisons Disease
Risk factors for serious side effects
prednisonefludrocortisone
  • Taking high doses of Rayos (prednisone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Rayos (prednisone) for a long time
Detailed Rayos (prednisone) risks & warnings »
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Taking other immunosuppressants
  • Long-term treatment
  • Not vaccinated against viral diseases
Detailed Fludrocortisone risks & warnings »
Pregnancy
Interactions
prednisonefludrocortisone
No interactions related info.
  • Fludrocortisone can interact with other drugs and vaccines.
Alcohol
prednisonefludrocortisone
  • Taking Rayos (prednisone) increases the risk of injury to your stomach. You should avoid drinking alcohol while taking this medicine because it can worsen stomach irritation. Tell your doctor right away if you experience stomach pain that does not go away or you get bloody/dark stools.
No alcohol related info.
Food
prednisonefludrocortisone
  • Take Rayos (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
No food related info.
Kidneys and liver
prednisonefludrocortisone
  • Rayos (prednisone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
No kidneys and liver related info.
Pain
prednisonefludrocortisone
No pain related info.
  • Taking Fludrocortisone increases the risk of injury to the lining of your stomach and intestine including irritation and tears. You should avoid alcohol/alcoholic beverages because it can worsen stomach irritation. Tell your doctor and get medical care right away if you have stomach pain or bloody/dark stools when you go to the bathroom.
Upsides and benefits
prednisonefludrocortisone
  • Rayos (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Rayos (prednisone) is available in a generic form.
  • Fludrocortisone is effective in correcting electrolyte imbalances associated with Addison's disease.
  • Generic is available.
  • Only need to take it once daily.
Downsides and risks
prednisonefludrocortisone
  • Rayos (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Rayos (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Rayos (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Fludrocortisone can cause reactivation of old infections such as Hepatits B, C, or tuberculosis.
  • Fludrocortisone can make it easier for you to get sick.
  • Fludrocortisone can interact with other drugs and vaccines.
  • While on Fludrocortisone, you may need to have blood tests done for monitoring.
Tips from our pharmacists for people taking the medication
prednisonefludrocortisone
  • Take Rayos (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Rayos (prednisone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Rayos (prednisone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Rayos (prednisone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • Rayos (prednisone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
  • Take Fludrocortisone in the morning if you're taking it once a day, with or without food.
  • If you're on Fludrocortisone for a long period of time, watch out for any symptoms of illness, and let your doctor know right away.
  • Let your doctor know you're on this medicine before you receive any vaccines.
  • Fludrocortisone can re-activate any old infections you may have. Let your doctor know if you have or had hepatitis B, C, or tuberculosis.
Learn more
More about prednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Rayos (prednisone)?
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More about fludrocortisoneSide effectsAlternativesFDA package insert
Have you used Fludrocortisone?
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