Compare prednisone vs. fludrocortisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Deltasone (prednisone)

Prescription only

Fludrocortisone

Prescription only
Calms down your immune system.

Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving an overactive immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.

4.8/ 7 average rating with 540 reviewsforprednisone
Treats electrolyte imbalance.

Fludrocortisone is one of the first choices used in Addison's disease to help maintain your electrolytes, but there are side effects.

Upsides
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
  • Fludrocortisone is effective in correcting electrolyte imbalances associated with Addison's disease.
  • Generic is available.
  • Only need to take it once daily.
Downsides
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Fludrocortisone can cause reactivation of old infections such as Hepatits B, C, or tuberculosis.
  • Fludrocortisone can make it easier for you to get sick.
  • Fludrocortisone can interact with other drugs and vaccines.
  • While on Fludrocortisone, you may need to have blood tests done for monitoring.
Used for
  • Addison's disease
  • Congential adrenal hyperplasia
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
Price
Lowest price near you
$3.28
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$15.01
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Reviews
540 
59%
think this treatment is worth it
45%
think this treatment works well
20%
think this treatment is a hassle

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Side effects
The Deltasone (prednisone) FDA package insert doesn’t have numbers about how common side effects are.
The Fludrocortisone FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Physicial Dependence

    Taking high doses of Deltasone (prednisone) for a long period of time

    ...and 2 more risk factors

  • Increased risk for infections

    Taking other medicines that weaken the immune system

    ...and 4 more risk factors

  • Eye problems

    Those with cataracts and/or glaucoma

    ...and 1 more risk factors

  • Changes in heart and kidney function

    Those who had a recent heart attack

    ...and 1 more risk factors

  • Effects on bone

    Taking Deltasone (prednisone) at high doses and/or for a long period of time

    ...and 2 more risk factors

  • Stomach problems

    History of stomach bleeding

    ...and 3 more risk factors

See more detailed risks and warnings
  • Lowered adrenal function

    Lowering dose or stopping too quickly especially after long-term treatment

    ...and 1 more risk factors

  • Increased risk for infections

    Taking other immunosuppressants

    ...and 4 more risk factors

  • Bone effects

    Dose of Fludrocortisone

    ...and 1 more risk factors

  • Stomach and intestinal problems

    History of stomach bleeding

    ...and 3 more risk factors

See more detailed risks and warnings