Compare prednisone vs. Hydrocortisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Deltasone (prednisone)

Prescription only
Calms down your immune system.

Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving an overactive immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.

3.5/ 5 average rating with 540 reviewsforprednisone
Treats itchy or irritated skin.

Anusol Hc (Hydrocortisone) is a good topical steroid to try for treating minor rashes or skin irritation.

Upsides
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
  • Relieves itchy and irritated skin.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
  • It's available over the counter in the drugstore.
  • Most people have very few side effects.
Downsides
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • It's not a strong steroid, so it doesn't work for everyone.
  • When used longer than a week, it can cause skin-thinning and make it harder for broken skin to heal.
Used for
  • Skin inflammation
  • Itching
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Cream, gel, or ointment
  • Lotion
  • Topical solution
Price
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Reviews
540 reviews so far
59%
saidit'sworth it
45%
saiditworked well
20%
saidit'sa big hassle

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Side effects
The Deltasone (prednisone) FDA package insert doesn’t have numbers about how common side effects are.
The Anusol Hc (Hydrocortisone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Physicial Dependence
    • Taking high doses of Deltasone (prednisone) for a long period of time
    • Young children
    • Stress such as trauma, injury, or infection
  • Increased risk for infections
    • Taking other medicines that weaken the immune system
    • Taking Deltasone (prednisone) for a long time
    • Those who are not vaccinated against viral illnesses
    • Coming into contact with people who have viral illness
    • History of bacterial or viral conditions
  • Eye problems
    • Those with cataracts and/or glaucoma
    • History of herpes simplex in the eye
  • Changes in heart and kidney function
    • Those who had a recent heart attack
    • History of heart failure, high blood pressure, and kidney problems
  • Effects on bone
    • Taking Deltasone (prednisone) at high doses and/or for a long period of time
    • Infants and young children
    • Age 60 or older
  • Stomach problems
    • History of stomach bleeding
    • History of stomach ulcers
    • History of Ulcerative Colitis
    • Taking Deltasone (prednisone) with other medicines that can also cause stomach problems
See more detailed risks and warnings
  • Increased risk for infections
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
  • Kaposi's sarcoma
    • Long-term treatment
  • Bone effects
    • Dose of Anusol Hc (Hydrocortisone)
    • Duration of treatment
See more detailed risks and warnings