Compare prednisone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Deltasone
(prednisone)

Medrol
(methylprednisolone)

Calms down your immune system. Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving the immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.Calms down your immune system. Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.8prednisone
Reviews for prednisone
59%
of people (All ages) say prednisone is worth it
45%
say it works well
20%
say it's a big hassle
540 reviews
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
Reviews for Medrol
59%
Same vs. prednisone
53%
-8% worse vs. prednisone
23%
+3% better vs. prednisone
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it
Side effects
prednisoneMedrol

The prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about prednisone side effects »

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »
How it works
prednisoneMedrol
Deltasone (prednisone) is a corticosteroid similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.Medrol (methylprednisolone) is a corticosteroid that is similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.
Type of medication
prednisoneMedrol
Prescription onlyPrescription only
Available as
prednisoneMedrol
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Injection
Used for
prednisoneMedrol
Risk factors for serious side effects
prednisoneMedrol
  • Taking high doses of Deltasone (prednisone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Deltasone (prednisone) for a long time
Detailed Deltasone (prednisone) risks & warnings »
  • Taking high doses of Medrol (methylprednisolone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Medrol (methylprednisolone) for a long time
Detailed Medrol (methylprednisolone) risks & warnings »
Pregnancy
Food
prednisoneMedrol
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
Kidneys and liver
prednisoneMedrol
  • Deltasone (prednisone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
  • Medrol (methylprednisolone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
Upsides and benefits
prednisoneMedrol
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
Downsides and risks
prednisoneMedrol
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
Tips from our pharmacists for people taking the medication
prednisoneMedrol
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Deltasone (prednisone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Deltasone (prednisone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Deltasone (prednisone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • Deltasone (prednisone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Medrol (methylprednisolone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Medrol (methylprednisolone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Medrol (methylprednisolone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • While you are on this medicine, don't get any live vaccines, unless approved by your doctor.
  • Medrol (methylprednisolone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
Learn more
More about prednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
More about MedrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it