Compare prednisone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Deltasone (prednisone)

Prescription only
Calms down your immune system.

Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving an overactive immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.

3.5/ 5 average rating with 540 reviewsforprednisone
Calms down your immune system.

Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.

3.7/ 5 average rating with 66 reviewsforMedrol
Upsides
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
Downsides
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Injection
Price
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Reviews
540 reviews so far
59%
saidit'sworth it
45%
saiditworked well
20%
saidit'sa big hassle

Have you used Deltasone (prednisone)?

Leave a review
66 reviews so far
59%
saidit'sworth it
53%
saiditworked well
23%
saidit'sa big hassle

Have you used Medrol (methylprednisolone)?

Leave a review
Side effects
The Deltasone (prednisone) FDA package insert doesn’t have numbers about how common side effects are.
The Medrol (methylprednisolone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Physicial Dependence
    • Taking high doses of Deltasone (prednisone) for a long period of time
    • Young children
    • Stress such as trauma, injury, or infection
  • Increased risk for infections
    • Taking other medicines that weaken the immune system
    • Taking Deltasone (prednisone) for a long time
    • Those who are not vaccinated against viral illnesses
    • Coming into contact with people who have viral illness
    • History of bacterial or viral conditions
  • Eye problems
    • Those with cataracts and/or glaucoma
    • History of herpes simplex in the eye
  • Changes in heart and kidney function
    • Those who had a recent heart attack
    • History of heart failure, high blood pressure, and kidney problems
  • Effects on bone
    • Taking Deltasone (prednisone) at high doses and/or for a long period of time
    • Infants and young children
    • Age 60 or older
  • Stomach problems
    • History of stomach bleeding
    • History of stomach ulcers
    • History of Ulcerative Colitis
    • Taking Deltasone (prednisone) with other medicines that can also cause stomach problems
See more detailed risks and warnings
  • Weakened immune system response to stress
    • Taking high doses of Medrol (methylprednisolone) for a long period of time
    • Young children
    • Stress such as trauma, injury, or infection
  • Increased risk for infections
    • Taking other medicines that weaken the immune system
    • Taking Medrol (methylprednisolone) for a long time
    • Those who are not vaccinated against viral illnesses
    • Coming into contact with people who have viral illness
    • History of bacterial or viral conditions
  • Changes in heart and kidney function
    • Those who had a recent heart attack
    • History of heart failure, high blood pressure, and kidney problems
  • Eye problems
    • Those with cataracts and/or glaucoma
    • History of herpes simplex in the eye
  • Harm to fetus (unborn baby)
    • Pregnant women
    • Women who can or plan to become pregnant
See more detailed risks and warnings