Compare Prednisone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Deltasone
(prednisone)

Medrol
(methylprednisolone)

Calms down your immune system. Deltasone (Prednisone) is a common oral corticosteroid that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.Calms down your immune system. Medrol (Methylprednisolone) is corticosteroid available in many forms (oral, injectable) that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.
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Coupons for Prednisone
Best available price for 10 (20mg) tablets of prednisone
Coupons for Medrol
Best available price for 21 (4mg) tablets of medrol
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.8Prednisone
Reviews for Prednisone
59%
of people (All ages) say Prednisone is worth it
45%
say it works well
20%
say it's a big hassle
540 reviews
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
Reviews for Medrol
59%
Same vs. Prednisone
53%
-8% worse vs. Prednisone
23%
+3% better vs. Prednisone
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it
Side effects
PrednisoneMedrol

The Prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisone side effects »

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »
How it works
PrednisoneMedrol
Deltasone (Prednisone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Medrol (Methylprednisolone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.
Type of medication
PrednisoneMedrol
Prescription onlyPrescription only
Available as
PrednisoneMedrol
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for
PrednisoneMedrol
Risk factors for serious side effects
PrednisoneMedrol
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
Detailed Deltasone (prednisone) risks & warnings »
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Duration of treatment
  • History of psychiatric conditions
  • Dose of Medrol (Methylprednisolone)
Detailed Medrol (methylprednisolone) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
PrednisoneMedrol
  • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
  • Useful in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
Food
PrednisoneMedrol
  • Take with food to decrease stomach upset.
  • Take with food to decrease stomach upset.
Kidneys and liver
PrednisoneMedrol
  • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Deltasone (Prednisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Deltasone (Prednisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
  • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Medrol (Methylprednisolone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Medrol (Methylprednisolone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
Upsides and benefits
PrednisoneMedrol
  • Steroid magic, can help you feel better, have more energy and get more appetite.
  • Useful for many conditions.
  • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
  • Long-term use in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
  • Steroid magic, can help you feel better, have more energy and get more appetite.
  • Useful in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
  • Useful in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
  • Available in many different forms, including injection, that will expose the rest of your body less of the medicine.
Downsides and risks
PrednisoneMedrol
  • Lots of side effects, especially with long term use.
  • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Prednisone.
  • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
  • Only available as an oral medicine so the rest of your body will be exposed to the medicine.
  • Lots of side effects, especially with long term use.
  • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Medrol.
  • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
Tips from our pharmacists for people taking the medication
PrednisoneMedrol
  • The dose and duration on how long you need the medicine depends on your condition and response.
  • Take it exactly as your doctor prescribed.
  • Take with food to decrease stomach upset.
  • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
  • Can cause changes in mood, blood pressure, blood sugar, and water retention.
  • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
  • A taper is is often needed to stop the medicine, especially if you've been on it for more than 1 week.
  • The dose and duration on how long you need the medicine depends on your condition and response.
  • Take it exactly as your doctor prescribed.
  • Take with food to decrease stomach upset.
  • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
  • Can cause changes in mood, blood pressure, blood sugar, and water retention.
  • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
  • A taper is often needed to stop the medicine, especially if you've been on it for more than 1 week.
Learn more
More about PrednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
More about MedrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it