Compare Prednisone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Deltasone
(Prednisone)

Medrol
(Methylprednisolone)

Calms down your immune system. Deltasone (Prednisone) is a common oral corticosteroid that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.Calms down your immune system. Medrol (Methylprednisolone) is corticosteroid available in many forms (oral, injectable) that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.
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Reviews & ratings
Filter group. All currently selected
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4.767485822306238Prednisone
Reviews for Deltasone (Prednisone)
59%
of people (All ages) say Deltasone (Prednisone) is worth it
44%
say it works well
20%
say it's a big hassle
529 reviews
Have you used Deltasone (Prednisone)?
Worth itNot sureNot worth it
Reviews for Medrol (Methylprednisolone)
57%
2% vs. Deltasone (Prednisone)
51%
+7% vs. Deltasone (Prednisone)
23%
3% vs. Deltasone (Prednisone)
Have you used Medrol (Methylprednisolone)?
Worth itNot sureNot worth it
Side effects
PrednisoneMedrol

The Prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisone side effects »

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »
How it works
PrednisoneMedrol
Deltasone (Prednisone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Medrol (Methylprednisolone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.
Type of medication
PrednisoneMedrol
Anti-inflammatory, Immunosuppressant
Corticosteroid
Prescription only
Anti-inflammatory, Immunosuppressant
Corticosteroid
Prescription only
Available as
PrednisoneMedrol
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
PrednisoneMedrol
Risk factors for serious side effects
PrednisoneMedrol
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
  • History of bacterial or viral conditions
  • Duration of treatment
    • History of psychiatric conditions
    • Dose of Deltasone (Prednisone)
    • Duration of treatment
    • Women of childbearing age
    • History of stomach bleeding
    • Active or history of stomach or duodenal ulcers
    • Ulcerative colitis
    • Taking Deltasone (Prednisone) with other medicine that can cause stomach problems
    Detailed Deltasone (Prednisone) risks & warnings »
    • Lowering dose or stopping too quickly especially after long-term treatment
    • Stress such as trauma, surgery or infection
    • Duration of treatment
      • History of psychiatric conditions
      • Dose of Medrol (Methylprednisolone)
      • Duration of treatment
      • Women of childbearing age
      • History of stomach bleeding
      • Active or history of stomach or duodenal ulcers
      • Ulcerative colitis
      • Taking Medrol (Methylprednisolone) with other medicine that can cause stomach problems
      • Long-term treatment
      • Not vaccinated against viral diseases
      • Contact with people who have viral illness
      • History of bacterial or viral conditions
      Detailed Medrol (Methylprednisolone) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      PrednisoneMedrol
      • Take with food to decrease stomach upset.
      • Take with food to decrease stomach upset.
      Kidneys and liver
      PrednisoneMedrol
      • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Deltasone (Prednisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Deltasone (Prednisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
      • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Medrol (Methylprednisolone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Medrol (Methylprednisolone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
      Upsides and benefits
      PrednisoneMedrol
      • Useful for many conditions.
      • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
      • Long-term use in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
      • Steroid magic, can help you feel better, have more energy and get more appetite.
      • Useful in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
      • Useful in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
      • Available in many different forms, including injection, that will expose the rest of your body less of the medicine.
      • Steroid magic, can help you feel better, have more energy and get more appetite.
      Downsides and risks
      PrednisoneMedrol
      • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Prednisone.
      • Only available as an oral medicine so the rest of your body will be exposed to the medicine.
      • Lots of side effects, especially with long term use.
      • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
      • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
      • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
      • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Medrol.
      • Lots of side effects, especially with long term use.
      • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
      • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
      • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
      Tips from our pharmacists for people taking the medication
      PrednisoneMedrol
      • A taper is is often needed to stop the medicine, especially if you've been on it for more than 1 week.
      • The dose and duration on how long you need the medicine depends on your condition and response.
      • Take it exactly as your doctor prescribed.
      • Take with food to decrease stomach upset.
      • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
      • Can cause changes in mood, blood pressure, blood sugar, and water retention.
      • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
      • A taper is often needed to stop the medicine, especially if you've been on it for more than 1 week.
      • The dose and duration on how long you need the medicine depends on your condition and response.
      • Take it exactly as your doctor prescribed.
      • Take with food to decrease stomach upset.
      • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
      • Can cause changes in mood, blood pressure, blood sugar, and water retention.
      • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
      Learn more
      More about PrednisoneSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Deltasone (Prednisone)?
      Worth itNot sureNot worth it
      More about MedrolSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Medrol (Methylprednisolone)?
      Worth itNot sureNot worth it