Compare Prednisone vs. Prednisolone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Deltasone
(prednisone)

Pred Forte
(prednisolone)

Calms down your immune system. Deltasone (Prednisone) is a common oral corticosteroid that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.Treats eye redness and swelling. Pred Forte (Prednisolone) is strong medicine for eye redness and swelling without exposing the rest of your body to the steroid medicine.
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Coupons for Prednisone
Best available price for 10 (20mg) tablets of prednisone
Coupons for Prednisolone
Best available price for 50 (15mg/5ml) syrups of prednisolone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.8Prednisone
Reviews for Deltasone (prednisone)
59%
of people (All ages) say Deltasone (prednisone) is worth it
45%
say it works well
20%
say it's a big hassle
540 reviews
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
Reviews for Pred Forte (prednisolone)
Not enough review data. Review it!
+41% better vs. Deltasone (prednisone)
Not enough review data. Review it!
-45% worse vs. Deltasone (prednisone)
Not enough review data. Review it!
+20% better vs. Deltasone (prednisone)
Have you used Pred Forte (prednisolone)?
Worth itNot sureNot worth it
Side effects
PrednisonePrednisolone

The Prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisone side effects »

The Prednisolone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisolone side effects »
How it works
PrednisonePrednisolone
Deltasone (Prednisone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Pred Forte (Prednisolone) is a steroid that lowers your immune response to allergens and reduces eye redness and swelling.
Type of medication
PrednisonePrednisolone
Prescription only
Prescription only
Available as
PrednisonePrednisolone
  • Pill
  • Extended release
  • Liquid
  • Eye drops
Used for
PrednisonePrednisolone
Risk factors for serious side effects
PrednisonePrednisolone
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
Detailed Deltasone (prednisone) risks & warnings »
  • Long-term use
  • History of glaucoma
Detailed Pred Forte (prednisolone) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
PrednisonePrednisolone
  • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
No price related info.
Food
PrednisonePrednisolone
  • Take with food to decrease stomach upset.
No food related info.
Kidneys and liver
PrednisonePrednisolone
  • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Deltasone (Prednisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Deltasone (Prednisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
No kidneys and liver related info.
Pain
PrednisonePrednisolone
No pain related info.
  • Let your doctor know if you have eye pain, pressure, infections, or changes in eye sight.
Upsides and benefits
PrednisonePrednisolone
  • Steroid magic, can help you feel better, have more energy and get more appetite.
  • Useful for many conditions.
  • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
  • Long-term use in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
  • Decreases swelling and redness in your eyes.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
Downsides and risks
PrednisonePrednisolone
  • Lots of side effects, especially with long term use.
  • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Prednisone.
  • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
  • Only available as an oral medicine so the rest of your body will be exposed to the medicine.
  • Available only as a prescription medication.
  • You need good hand-eye coordination to get the eye drops into your eyes.
  • Can cause or worsen certain eye conditions.
Tips from our pharmacists for people taking the medication
PrednisonePrednisolone
  • The dose and duration on how long you need the medicine depends on your condition and response.
  • Take it exactly as your doctor prescribed.
  • Take with food to decrease stomach upset.
  • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
  • Can cause changes in mood, blood pressure, blood sugar, and water retention.
  • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
  • A taper is is often needed to stop the medicine, especially if you've been on it for more than 1 week.
  • Shake the eye drops well before using.
  • Press your finger gently on the inner corner of your eye after the drops are in to keep them there.
  • Wait 1 minute between each drop if you're giving yourself more than 1 drop.
  • If you have other eye drops, wait 5 minutes in between different sets of eye drops.
  • If your symptoms don't get better after 2 days, you may need to try a different medicine.
  • Let your doctor know if you have eye pain, pressure, infections, or changes in eye sight.
Learn more
More about PrednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
More about PrednisoloneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pred Forte (prednisolone)?
Worth itNot sureNot worth it