Compare prednisone vs. Prednisolone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Deltasone
(prednisone)

Pred Forte
(prednisolone)

Calms down your immune system. Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving the immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.Treats eye redness and swelling. Pred Forte (Prednisolone) is strong medicine for eye redness and swelling without exposing the rest of your body to the steroid medicine.
Reviews & ratings
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Filter group. All currently selected
4.8prednisone
Reviews for prednisone
59%
of people (All ages) say prednisone is worth it
45%
say it works well
20%
say it's a big hassle
540 reviews
Have you used Deltasone (prednisone)?
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Have you used Pred Forte (prednisolone)?
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Side effects
prednisonePrednisolone

The prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about prednisone side effects »

The Prednisolone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisolone side effects »
How it works
prednisonePrednisolone
Deltasone (prednisone) is a corticosteroid similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.Pred Forte (Prednisolone) is a steroid that lowers your immune response to allergens and reduces eye redness and swelling.
Type of medication
prednisonePrednisolone
Prescription onlyPrescription only
Available as
prednisonePrednisolone
  • Pill
  • Delayed release pill
  • Liquid
  • Eye drops
Used for
prednisonePrednisolone
Risk factors for serious side effects
prednisonePrednisolone
  • Taking high doses of Deltasone (prednisone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Deltasone (prednisone) for a long time
Detailed Deltasone (prednisone) risks & warnings »
  • Long-term use
  • History of glaucoma
Detailed Pred Forte (prednisolone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
prednisonePrednisolone
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
No food related info.
Kidneys and liver
prednisonePrednisolone
  • Deltasone (prednisone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
No kidneys and liver related info.
Pain
prednisonePrednisolone
No pain related info.
  • Let your doctor know if you have eye pain, pressure, infections, or changes in eye sight.
Upsides and benefits
prednisonePrednisolone
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
  • Decreases swelling and redness in your eyes.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
Downsides and risks
prednisonePrednisolone
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Available only as a prescription medication.
  • You need good hand-eye coordination to get the eye drops into your eyes.
  • Can cause or worsen certain eye conditions.
Tips from our pharmacists for people taking the medication
prednisonePrednisolone
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Deltasone (prednisone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Deltasone (prednisone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Deltasone (prednisone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • Deltasone (prednisone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
  • Shake the eye drops well before using.
  • Press your finger gently on the inner corner of your eye after the drops are in to keep them there.
  • Wait 1 minute between each drop if you're giving yourself more than 1 drop.
  • If you have other eye drops, wait 5 minutes in between different sets of eye drops.
  • If your symptoms don't get better after 2 days, you may need to try a different medicine.
  • Let your doctor know if you have eye pain, pressure, infections, or changes in eye sight.
Learn more
More about prednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Deltasone (prednisone)?
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More about PrednisoloneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pred Forte (prednisolone)?
Worth itNot sureNot worth it