Compare Premarin Vaginal Cream vs. Alora

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves vaginal dryness and pain due to menopause.

Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.

Relieves hot flashes and vaginal dryness due to menopause and strengthens your bones.

Alora (estradiol patch) treats symptoms from low estrogen, and it may have fewer side effects than oral estrogen pills.

Upsides
  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Alora (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
  • You need to replace Alora (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
Used for
  • Vaginal dryness and inflammation
  • Painful intercourse from menopause
  • Treats hot flashes, night sweats and flushing in women in menopause
  • Treats vaginal changes in women in menopause
  • Treats low estrogen in women
  • Prevents bone thinning in women in menopause
Dosage forms
  • Vaginal cream, gel, or ointment
  • Patch
Price
No pricing information available
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Side effects
31possible side effects
  • Any side effect
    90%
  • Headache
    28%
  • Infection
    23%
  • Pain
    20%
  • Abdominal pain
    17%
  • Back pain
    13%
  • Pharyngitis
    12%
  • Dyspepsia
    11%
  • Flu syndrome
    10%
  • Rhinitis
    10%
  • Myalgia
    9%
  • Upper respiratory infection
    9%
  • Asthenia
    8%
  • Arthralgia
    7%
  • Insomnia
    7%
  • Sinusitis
    7%
  • Breast pain
    7%
  • Accidental injury
    6%
  • Diarrhea
    6%
  • Flatulence
    6%
  • Nausea
    6%
  • Depression
    5%
  • Pruritus
    5%
  • Vaginal moniliasis
    5%
  • Vaginitis
    5%
  • Dizziness
    4%
  • Cough increased
    4%
  • Leukorrhea
    4%
  • Leg cramps
    3%
  • Nervousness
    2%
  • Vaginal hemorrhage
    2%
See more detailed side effects
31possible side effects
  • Vaginal bleeding
    33%
  • Headache
    21%
  • Lung infection
    16%
  • Pain
    9%
  • Sinus infection
    8%
  • Vaginal inflammation
    8%
  • Breast pain
    7%
  • Back pain
    6%
  • Skin irritation
    6%
  • Accidental injury
    5%
  • Gas
    5%
  • Trouble sleeping
    5%
  • Itchiness
    5%
  • Nausea
    4%
  • Flu like symptoms
    3%
  • Stomach pain
    3%
  • Diarrhea
    3%
  • Depression
    3%
  • Airway inflammation
    3%
  • Cough
    3%
  • Rash
    3%
  • Weakness
    2%
  • Constipation
    2%
  • Swelling of arms and legs
    2%
  • Muscle aches
    2%
  • Anxiety
    2%
  • Sore throat
    2%
  • Breast growth
    2%
  • Bladder infection
    2%
  • White or yellow vaginal discharge
    2%
  • Breast tumor
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Memory loss
  • Gallbladder problems
  • Serious allergic reaction
    • Prior severe allergic reaction to Premarin Vaginal Cream (Conjugated Estrogens)
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings