Compare Premarin Vaginal Cream vs. Alora

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin Vaginal Cream
(conjugated estrogens)

Alora
(estradiol patch)

Relieves vaginal dryness and pain due to menopause. Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.Relieves hot flashes and vaginal dryness due to menopause and strengthens your bones. Alora (estradiol patch) treats symptoms from low estrogen, and it may have fewer side effects than oral estrogen pills.
Reviews & ratings
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Have you used Premarin Vaginal Cream (conjugated estrogens)?
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Have you used Alora (estradiol patch)?
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Side effects
Premarin Vaginal CreamAlora
  • Any side effect 8%
  • Abdominal pain 5%
  • Back pain 2%
  • Vaginal hemorrhage 14%
  • Arthralgia 2%
  • Upper respiratory infection 1%
More Premarin Vaginal Cream side effects »
  • Breast pain 7%
  • Heartburn 8%
  • Stomach pain 3%
  • Weakness 3%
More Alora side effects »
How it works
Premarin Vaginal CreamAlora
Premarin Vaginal Cream (Conjugated Estrogens) is a topical medication that replaces estrogen hormones in the vagina to rebuild vaginal tissue and make vaginal sex more comfortable.Alora (estradiol patch) replaces an estrogen hormone that your body loses during and after menopause. Higher levels of the hormone relieve symptoms of low estrogen, menopause, and prevent bone loss.
Type of medication
Premarin Vaginal CreamAlora
Prescription onlyPrescription only
Available as
Premarin Vaginal CreamAlora
  • Vaginal cream, gel, or ointment
  • Patch
Used for
Premarin Vaginal CreamAlora
  • Vaginal Dryness And Inflammation
  • Treats Hot Flashes Night Sweats And Flushing In Women In Menopause
Risk factors for serious side effects
Premarin Vaginal CreamAlora
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Premarin Vaginal Cream (conjugated estrogens) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Alora (estradiol patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Pain
Premarin Vaginal CreamAlora
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
No pain related info.
Weight
Premarin Vaginal CreamAlora
No weight related info.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
Premarin Vaginal CreamAlora
  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Alora (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
Downsides and risks
Premarin Vaginal CreamAlora
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
  • You need to replace Alora (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
Tips from our pharmacists for people taking the medication
Premarin Vaginal CreamAlora
  • Your doctor will tell you how often to use Premarin Vaginal Cream (Conjugated Estrogens). If you're taking Premarin Vaginal Cream (Conjugated Estrogens) regularly, use it around the same time each day.
  • Attach the applicator to the tube. Once the dose is measured, insert the applicator deeply into your vagina, and press the plunger to release all the medicine. Clean the applicator after each use.
  • More effective if you use it at bedtime.
  • Consider wearing a panty liner after use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your belly button on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of the skin to lower the risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to prevent exposing others to the medicine. Don't flush them down the toilet.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
Learn more
More about Premarin Vaginal CreamSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Premarin Vaginal Cream (conjugated estrogens)?
Worth itNot sureNot worth it
More about AloraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Alora (estradiol patch)?
Worth itNot sureNot worth it