Compare Premarin Vaginal Cream vs. Climara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin Vaginal Cream
(conjugated estrogens)

Climara
(estradiol patch)

Relieves vaginal dryness and pain due to menopause. Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Climara (estradiol patch) is a treatment for low estrogen that is used only once weekly, and it may have fewer side effects than oral estrogen pills.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Premarin Vaginal Cream (conjugated estrogens)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it
Side effects
Premarin Vaginal CreamClimara
  • Any side effect 8%
  • Abdominal pain 5%
  • Back pain 2%
  • Vaginal hemorrhage 14%
  • Arthralgia 2%
  • Upper respiratory infection 1%
More Premarin Vaginal Cream side effects »
  • Breast pain 1%
  • Sinus infection 1%
  • Stuffy nose 1%
  • Swelling of arms and legs 7%
  • Stomach pain 3%
  • Pain 1%
More Climara side effects »
How it works
Premarin Vaginal CreamClimara
Premarin Vaginal Cream (Conjugated Estrogens) is a topical medication that replaces estrogen hormones in the vagina to rebuild vaginal tissue and make vaginal sex more comfortable.The Climara (estradiol patch) replaces estrogen that your body loses during and after menopause. Higher levels of estrogen help relieve symptoms of menopause and prevent bone loss.
Type of medication
Premarin Vaginal CreamClimara
Prescription onlyPrescription only
Available as
Premarin Vaginal CreamClimara
  • Vaginal cream, gel, or ointment
  • Patch
Used for
Premarin Vaginal CreamClimara
  • Vaginal Dryness And Inflammation
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
Premarin Vaginal CreamClimara
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Premarin Vaginal Cream (conjugated estrogens) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Climara (estradiol patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Pain
Premarin Vaginal CreamClimara
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
No pain related info.
Weight
Premarin Vaginal CreamClimara
No weight related info.
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
Upsides and benefits
Premarin Vaginal CreamClimara
  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Climara (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Climara (estradiol patch) is available as a generic product, which lowers the cost.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
Downsides and risks
Premarin Vaginal CreamClimara
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
  • The patch can fall off, especially if you like to regularly swim, take baths or use saunas or steamrooms.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Climara (estradiol patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, underactive thyroid and migraines.
  • If you're only having vaginal dryness or inflammation and not hot flashes, it's better to use creams that you can apply to the affected area instead of Climara (estradiol patch).
Tips from our pharmacists for people taking the medication
Premarin Vaginal CreamClimara
  • Your doctor will tell you how often to use Premarin Vaginal Cream (Conjugated Estrogens). If you're taking Premarin Vaginal Cream (Conjugated Estrogens) regularly, use it around the same time each day.
  • Attach the applicator to the tube. Once the dose is measured, insert the applicator deeply into your vagina, and press the plunger to release all the medicine. Clean the applicator after each use.
  • More effective if you use it at bedtime.
  • Consider wearing a panty liner after use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly or the upper areas of your buttocks as directed by the manufacturer. Don't put it on your waistline or on your breasts. Press the patch firmly in place for at least 10 seconds, especially around the edges.
  • Replace the patch every 7 days on a different area of your skin to prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Should not be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
Learn more
More about Premarin Vaginal CreamSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Premarin Vaginal Cream (conjugated estrogens)?
Worth itNot sureNot worth it
More about ClimaraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it