Compare Premarin Vaginal Cream vs. Combipatch

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin Vaginal Cream (Conjugated Estrogens)

Prescription only
Relieves vaginal dryness and pain due to menopause.

Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.

Treats low estrogen and relieves menopause symptoms.

Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.

Upsides
  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Vaginal dryness and inflammation
  • Painful intercourse from menopause
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
Dosage forms
  • Vaginal cream, gel, or ointment
  • Patch
Price
No pricing information available
Lowest price near you
$168.57
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Reviews
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Side effects
10possible side effects
  • Any side effect
    90%
  • Headache
    28%
  • Infection
    23%
  • Pain
    20%
  • Abdominal pain
    17%
  • Back pain
    13%
  • Pharyngitis
    12%
  • Dyspepsia
    11%
  • Flu syndrome
    10%
  • Rhinitis
    10%
See more detailed side effects
10possible side effects
  • Breast pain
    34%
  • Menstrual cramps
    30%
  • Headache
    25%
  • Skin irritation
    20%
  • Pain
    19%
  • Stuffy nose
    19%
  • Menstrual problems
    17%
  • Back pain
    15%
  • Flu like symptoms
    14%
  • Diarrhea
    14%
See more detailed side effects
Risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 2 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Serious allergic reaction

    Prior severe allergic reaction to Premarin Vaginal Cream (Conjugated Estrogens)

  • Harm to fetus

    Women of childbearing age

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Dementia

    Aged 65 or older

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings