Compare Premarin Vaginal Cream vs. Elestrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin Vaginal Cream (Conjugated Estrogens)

Prescription only

Elestrin (Estradiol gel)

Prescription only
Relieves vaginal dryness and pain due to menopause.

Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.

Relieves hot flashes due to menopause.

Elestrin (Estradiol gel) is a good, easy-to-use option if you don’t want to use pills or patches with estrogen hormones.

Upsides
  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Elestrin (Estradiol gel) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Elestrin (Estradiol gel) is good for people who don't want to or can't take daily pills.
  • Elestrin (Estradiol gel) has fewer side effects than birht control pills since there are lower amounts of estrogen.
  • Most people start to feel better within 3-4 weeks of starting Elestrin (Estradiol gel).
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
  • Taking Elestrin (Estradiol gel) increases your risk for many conditions, like endometrial or breast cancer, dementia, heart disease, and blood clots.
  • You have to use Elestrin (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Not a good option for people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Vaginal dryness and inflammation
  • Painful intercourse from menopause
Dosage forms
  • Vaginal cream, gel, or ointment
  • Gel
Price
No pricing information available
Lowest price near you
$103.46
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Reviews
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Side effects
10possible side effects
  • Any side effect
    90%
  • Headache
    28%
  • Infection
    23%
  • Pain
    20%
  • Abdominal pain
    17%
  • Back pain
    13%
  • Pharyngitis
    12%
  • Dyspepsia
    11%
  • Flu syndrome
    10%
  • Rhinitis
    10%
See more detailed side effects
4possible side effects
  • Unusual vaginal bleeding
    9%
  • Common cold
    9%
  • Breast pain
    8%
  • Lung infection
    4%
See more detailed side effects
Risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 2 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Serious allergic reaction

    Prior severe allergic reaction to Premarin Vaginal Cream (Conjugated Estrogens)

  • Harm to fetus

    Women of childbearing age

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Dementia

    Age 65 or older

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings