Compare Premarin Vaginal Cream vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves vaginal dryness and pain due to menopause.

Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.

Relieves vaginal dryness due to menopause.

Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.

3.3/ 5 average rating with 56 reviewsforEstring
Upsides
  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
  • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Vaginal dryness and inflammation
  • Painful intercourse from menopause
  • Vaginal dryness and inflammation
Dosage forms
  • Vaginal cream, gel, or ointment
  • Vaginal ring
Price
No pricing information available
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Reviews
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56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle

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Side effects
31possible side effects
  • Any side effect
    90%
  • Headache
    28%
  • Infection
    23%
  • Pain
    20%
  • Abdominal pain
    17%
  • Back pain
    13%
  • Pharyngitis
    12%
  • Dyspepsia
    11%
  • Flu syndrome
    10%
  • Rhinitis
    10%
  • Myalgia
    9%
  • Upper respiratory infection
    9%
  • Asthenia
    8%
  • Arthralgia
    7%
  • Insomnia
    7%
  • Sinusitis
    7%
  • Breast pain
    7%
  • Accidental injury
    6%
  • Diarrhea
    6%
  • Flatulence
    6%
  • Nausea
    6%
  • Depression
    5%
  • Pruritus
    5%
  • Vaginal moniliasis
    5%
  • Vaginitis
    5%
  • Dizziness
    4%
  • Cough increased
    4%
  • Leukorrhea
    4%
  • Leg cramps
    3%
  • Nervousness
    2%
  • Vaginal hemorrhage
    2%
See more detailed side effects
20possible side effects
  • Headache
    13%
  • Leukorrhea
    7%
  • Back Pain
    6%
  • Genital Moniliasis
    6%
  • Upper Respiratory Tract Infection
    5%
  • Vaginitis
    5%
  • Vaginal Discomfort/Pain
    5%
  • Arthritis
    4%
  • Insomnia
    4%
  • Abdominal Pain
    4%
  • Sinusitis
    4%
  • Vaginal Hemorrhage
    4%
  • Asymptomatic Genital Bacterial Growth
    4%
  • Arthralgia
    3%
  • Nausea
    3%
  • Flu-Like Symptoms
    3%
  • Skeletal Pain
    2%
  • Urinary Tract Infection
    2%
  • Hot Flushes
    2%
  • Family Stress
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Memory loss
  • Gallbladder problems
  • Serious allergic reaction
    • Prior severe allergic reaction to Premarin Vaginal Cream (Conjugated Estrogens)
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings