Compare Premarin Vaginal Cream vs. Femring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin Vaginal Cream
(Conjugated Estrogens)

Femring
(Estradiol Acetate Vaginal Ring)

Relieves vaginal dryness and pain due to menopause. Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.Relieves hot flashes and vaginal dryness due to menopause. Femring (Estradiol Acetate Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.
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Reviews & ratings
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Reviews for Femring (Estradiol Acetate Vaginal Ring)
37%
13% vs. Premarin Vaginal Cream (Conjugated Estrogens)
13%
37% vs. Premarin Vaginal Cream (Conjugated Estrogens)
17%
17% vs. Premarin Vaginal Cream (Conjugated Estrogens)
Side effects
Premarin Vaginal CreamFemring
  • Any side effect 8%
  • Abdominal pain 6%
  • Vaginitis 6%
  • Leg cramps 5%
  • Passing gas 4%
  • Thick vaginal discharge 4%
  • Vaginal moniliasis 4%
  • Sinus inflammation 4%
  • Headache 4%
  • Cough increased 3%
More Premarin Vaginal Cream side effects »
  • Breast tenderness 9%
  • Vaginal candidiasis 8%
  • Vaginal bleeding between periods 8%
  • Abdominal distension 4%
  • Uterine pain 4%
  • Urinary tract infection 2%
  • Sinus inflammation 2%
  • Back pain 2%
  • Headache 1%
More Femring side effects »
How it works
Premarin Vaginal CreamFemring
Premarin Vaginal Cream (Conjugated Estrogens) is a topical medication that replaces estrogen hormones in the vagina to rebuild vaginal tissue and make vaginal sex more comfortable.Femring (Estradiol Acetate Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.
Type of medication
Premarin Vaginal CreamFemring
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Available as
Premarin Vaginal CreamFemring
  • Vaginal cream, gel, or ointment
  • Vaginal ring
Used for (click to learn more)
Premarin Vaginal CreamFemring
  • Vaginal dryness and inflammation
  • Hot flashes and night sweats
Risk factors for serious side effects
Premarin Vaginal CreamFemring
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
      • Prior severe allergic reaction to Premarin Vaginal Cream (Conjugated Estrogens)
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Premarin Vaginal Cream (Conjugated Estrogens) risks & warnings »
      • Using estrogen for more than one year
      • Personal or family history of breast cancer
      • Duration of use
      • Personal or family history of blood clots
      • Obesity
      • Systemic lupus erythematosus (SLE)
      • Smoking
      • Obesity
      • High blood pressure
      • High blood sugar
      • High cholesterol
      • Age 50 or older
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Femring (Estradiol Acetate Vaginal Ring) risks & warnings »
      Pregnancy category
      Premarin Vaginal CreamFemring
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
      • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
      • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
      • Femring (Estradiol Acetate Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
      • You don’t have to remove Femring (Estradiol Acetate Vaginal Ring) to treat a vaginal infection or have sex.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Premarin Vaginal CreamFemring
      • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
      • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
      • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
      • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
      • Femring (Estradiol Acetate Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
      • Good option for people who don't want to take oral pills.
      • Generally works well with fewer side effects.
      • Many women think Femring (Estradiol Acetate Vaginal Ring) is easy to insert and comfortable to use.
      • In a 12-week study, Femring (Estradiol Acetate Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
      • Femring (Estradiol Acetate Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
      • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
      Downsides and risks
      Premarin Vaginal CreamFemring
      • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
      • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
      • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
      • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
      • Femring (Estradiol Acetate Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
      • The ring can fall out without you noticing it.
      • Increases your risk of endometrial (uterine cancer).
      • If you have your uterus, you might need to use Femring (Estradiol Acetate Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
      • Can be expensive since it's only available as a brand name product.
      Tips from our pharmacists for people taking the medication
      Premarin Vaginal CreamFemring
      • Your doctor will tell you how often to use Premarin Vaginal Cream (Conjugated Estrogens). If you're taking Premarin Vaginal Cream (Conjugated Estrogens) regularly, use it around the same time each day.
      • Attach the applicator to the tube. Once the dose is measured, insert the applicator deeply into your vagina, and press the plunger to release all the medicine. Clean the applicator after each use.
      • More effective if you use it at bedtime.
      • Consider wearing a panty liner after use.
      • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
      • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
      • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
      • You don’t have to remove Femring (Estradiol Acetate Vaginal Ring) to treat a vaginal infection or have sex.
      • It can take up to 2 to 3 weeks to feel the full benefits.
      • Tell your doctor about any unusual vaginal bleeding.
      • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
      Learn more
      More about Premarin Vaginal CreamSide effectsReviews & ratingsAlternativesFDA package insert
      More about FemringSide effectsReviews & ratingsAlternativesFDA package insert