Compare Premarin Vaginal Cream vs. Provera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin Vaginal Cream
(Conjugated Estrogens)

Provera
(Medroxyprogesterone)

Relieves vaginal dryness and pain due to menopause. Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.
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Side effects
Premarin Vaginal CreamProvera
  • Any side effect 8%
  • Abdominal pain 6%
  • Vaginitis 6%
  • Leg cramps 5%
  • Passing gas 4%
  • Thick vaginal discharge 4%
  • Vaginal moniliasis 4%
  • Sinus inflammation 4%
  • Headache 4%
  • Cough increased 3%
More Premarin Vaginal Cream side effects »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
How it works
Premarin Vaginal CreamProvera
Premarin Vaginal Cream (Conjugated Estrogens) is a topical medication that replaces estrogen hormones in the vagina to rebuild vaginal tissue and make vaginal sex more comfortable.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.
Type of medication
Premarin Vaginal CreamProvera
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Progestin
Prescription only
Available as
Premarin Vaginal CreamProvera
  • Vaginal cream, gel, or ointment
  • Pill
Used for (click to learn more)
Premarin Vaginal CreamProvera
  • Vaginal dryness and inflammation
  • Amenorrhea
Risk factors for serious side effects
Premarin Vaginal CreamProvera
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
      • Prior severe allergic reaction to Premarin Vaginal Cream (Conjugated Estrogens)
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Premarin Vaginal Cream (Conjugated Estrogens) risks & warnings »
      • Personal or family history of breast cancer
      • Family history of ovarian cancer
      • Personal or family history of blood clots
      • Smoking
      • Obesity
      • Hypertension
      • Diabetes
      • High cholesterol
      • Systemic lupus erythematosus (SLE)
      • History of depression
      • History of liver problems
      • Women of childbearing age
      Detailed Provera (Medroxyprogesterone) risks & warnings »
      Pregnancy category
      Premarin Vaginal CreamProvera
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
      • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
      • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
      No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.
      • Can cause headache, weight gain, breast tenderness, or changes in mood.
      Upsides and benefits
      Premarin Vaginal CreamProvera
      • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
      • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
      • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
      • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
      • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
      • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
      • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
      Downsides and risks
      Premarin Vaginal CreamProvera
      • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
      • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
      • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
      • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
      • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
      Tips from our pharmacists for people taking the medication
      Premarin Vaginal CreamProvera
      • Your doctor will tell you how often to use Premarin Vaginal Cream (Conjugated Estrogens). If you're taking Premarin Vaginal Cream (Conjugated Estrogens) regularly, use it around the same time each day.
      • Attach the applicator to the tube. Once the dose is measured, insert the applicator deeply into your vagina, and press the plunger to release all the medicine. Clean the applicator after each use.
      • More effective if you use it at bedtime.
      • Consider wearing a panty liner after use.
      • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
      • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
      • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
      • Can cause headache, weight gain, breast tenderness, or changes in mood.
      • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
      Learn more
      More about Premarin Vaginal CreamSide effectsReviews & ratingsAlternativesFDA package insert
      More about ProveraSide effectsReviews & ratingsAlternativesFDA package insert