Compare Premarin vs. Estradiol Norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin
(conjugated estrogens)

Activella
(estradiol / norethindrone)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.78Premarin
Reviews for Premarin
50%
of people (All ages) say Premarin is worth it
43%
say it works well
11%
say it's a big hassle
154 reviews
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Side effects
PremarinEstradiol Norethindrone
  • Vaginal hemorrhage 13%
  • Abdominal pain 5%
  • Breast pain 3%
  • Flatulence 4%
  • Pain 1%
  • Leukorrhea 3%
  • Endometrial hyperplasia 5%
  • Vaginitis 5%
  • Insomnia 1%
More Premarin side effects »
  • Breast Pain 24%
  • Upper Respiratory Tract Infection 18%
  • Headache 16%
  • Sinusitis 7%
  • Insomnia 6%
  • Back Pain 6%
  • Post-Menopausal Bleeding 5%
  • Uterine Fibroid 5%
  • Infection Viral 4%
  • Moniliasis Genital 4%
More Estradiol Norethindrone side effects »
How it works
PremarinEstradiol Norethindrone
Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
PremarinEstradiol Norethindrone
Prescription onlyPrescription only
Available as
PremarinEstradiol Norethindrone
  • Pill
  • Pill
Used for
PremarinEstradiol Norethindrone
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
PremarinEstradiol Norethindrone
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Premarin (conjugated estrogens) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Activella (estradiol / norethindrone) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Pain
PremarinEstradiol Norethindrone
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
No pain related info.
Weight
PremarinEstradiol Norethindrone
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Activella (Estradiol / Norethindrone) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
PremarinEstradiol Norethindrone
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
Downsides and risks
PremarinEstradiol Norethindrone
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
PremarinEstradiol Norethindrone
  • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
  • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
  • Tell your doctor about any unusual vaginal bleeding.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about PremarinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Premarin (conjugated estrogens)?
Worth itNot sureNot worth it
More about Estradiol NorethindroneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Activella (estradiol / norethindrone)?
Worth itNot sureNot worth it