Compare Premarin vs. Estradiol Norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin
(Conjugated Estrogens)

Activella
(Estradiol / Norethindrone)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.779220779220779Premarin
Reviews for Premarin (Conjugated Estrogens)
50%
of people say Premarin (Conjugated Estrogens) is worth it
43%
say it works well
11%
say it's a big hassle

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Side effects
PremarinEstradiol Norethindrone
  • Abdominal pain 5%
  • Back pain 4%
  • Muscle weakness 4%
  • Breast pain 4%
  • Passing gas 4%
  • Thick vaginal discharge 3%
  • Vaginal moniliasis 2%
  • Nervousness 2%
  • Itching 2%
  • Leg cramps 2%
More Premarin side effects »
  • Excessive vaginal bleeding 14%
  • Injury accidental 13%
  • Endometrial thickening 6%
  • Back pain 6%
  • Sinus inflammation 5%
  • Common cold 3%
  • Headache 3%
  • Weight increase 3%
  • "stomach flu" 2%
  • Other events 2%
More Estradiol Norethindrone side effects »
How it works
PremarinEstradiol Norethindrone
Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
PremarinEstradiol Norethindrone
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Available as
PremarinEstradiol Norethindrone
  • Pill
  • Pill
Used for (click to learn more)
PremarinEstradiol Norethindrone
  • Hot flashes and night sweats
  • Hot flashes and night sweats
Risk factors for serious side effects
PremarinEstradiol Norethindrone
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
      • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Premarin (Conjugated Estrogens) risks & warnings »
      • Using estrogen for more than one year
      • Personal or family history of breast cancer
      • Duration of use
      • Personal or family history of blood clots
      • Obesity
      • Systemic lupus erythematosus (SLE)
      • Women of childbearing age
      • High levels of triglycerides
      • Family history of ovarian cancer
      Detailed Activella (Estradiol / Norethindrone) risks & warnings »
      Pregnancy category
      PremarinEstradiol Norethindrone
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
      No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      PremarinEstradiol Norethindrone
      • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
      • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
      • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
      • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
      • Improves mood, energy, and mental alertness for some people.
      • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
      • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
      • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
      • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
      • Improves mood, energy, and mental alertness for some people.
      Downsides and risks
      PremarinEstradiol Norethindrone
      • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
      • Increases your risk of uterine and breast cancer.
      • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
      • Can't be used in people with liver problems.
      • Can be expensive since it's only available as a brand name product.
      • Increases your risk of developing blood clots and stroke.
      • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
      • You may get irregular bleeding and spotting that can last a few months to a year.
      • Increases your risk of developing blood clots and stroke.
      Tips from our pharmacists for people taking the medication
      PremarinEstradiol Norethindrone
      • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
      • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
      • Can cause nausea, dizziness, bloating and breast tenderness.
      • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
      • Tell your doctor about any unusual vaginal bleeding.
      • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
      • Can cause nausea, dizziness, bloating, and breast tenderness.
      • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
      • Tell your doctor about any unusual vaginal bleeding.
      Learn more
      More about PremarinSide effectsReviews & ratingsAlternativesFDA package insert
      More about Estradiol NorethindroneSide effectsReviews & ratingsAlternativesFDA package insert