Compare Premarin vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

3.5/ 5 average rating with 154 reviewsforPremarin
Relieves vaginal dryness due to menopause.

Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.

3.3/ 5 average rating with 56 reviewsforEstring
Upsides
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
Downsides
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
  • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
  • Advanced prostate cancer
  • Vaginal dryness and inflammation
Dosage forms
  • Pill
  • Vaginal ring
Price
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Reviews
154 reviews so far
50%
saidit'sworth it
43%
saiditworked well
11%
saidit'sa big hassle

Have you used Premarin (Conjugated Estrogens)?

Leave a review
56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle

Have you used Estring (Estradiol Vaginal Ring)?

Leave a review
Side effects
28possible side effects
  • Headache
    13%
  • Abdominal pain
    9%
  • Breast pain
    7%
  • Nausea
    5%
  • Asthenia
    4%
  • Back pain
    4%
  • Pain
    4%
  • Flatulence
    4%
  • Insomnia
    4%
  • Leukorrhea
    4%
  • Vaginal moniliasis
    4%
  • Leg cramps
    3%
  • Depression
    3%
  • Pruritus
    3%
  • Vaginitis
    3%
  • Pelvic pain
    2%
  • Hypertension
    2%
  • Diarrhea
    2%
  • Dyspepsia
    2%
  • Weight gain
    2%
  • Emotional lability
    2%
  • Hypertonia
    2%
  • Acne
    2%
  • Alopecia
    2%
  • Breast enlargement
    2%
  • Breast neoplasm
    2%
  • Cervix disorder
    2%
  • Vaginal hemorrhage
    2%
See more detailed side effects
20possible side effects
  • Headache
    13%
  • Leukorrhea
    7%
  • Back Pain
    6%
  • Genital Moniliasis
    6%
  • Upper Respiratory Tract Infection
    5%
  • Vaginitis
    5%
  • Vaginal Discomfort/Pain
    5%
  • Arthritis
    4%
  • Insomnia
    4%
  • Abdominal Pain
    4%
  • Sinusitis
    4%
  • Vaginal Hemorrhage
    4%
  • Asymptomatic Genital Bacterial Growth
    4%
  • Arthralgia
    3%
  • Nausea
    3%
  • Flu-Like Symptoms
    3%
  • Skeletal Pain
    2%
  • Urinary Tract Infection
    2%
  • Hot Flushes
    2%
  • Family Stress
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Memory loss
  • Gallbladder problems
  • Serious allergic reaction
    • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings