Compare Premarin vs. Minivelle

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin
(Conjugated Estrogens)

Minivelle
(Estradiol Patch)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Relieves hot flashes due to menopause and lowers your risk of osteoporosis. The Minivelle (Estradiol Patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.779220779220779Premarin
Reviews for Premarin (Conjugated Estrogens)
50%
of people say Premarin (Conjugated Estrogens) is worth it
43%
say it works well
11%
say it's a big hassle

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Side effects
PremarinMinivelle
  • Abdominal pain 5%
  • Back pain 4%
  • Muscle weakness 4%
  • Breast pain 4%
  • Passing gas 4%
  • Thick vaginal discharge 3%
  • Vaginal moniliasis 2%
  • Nervousness 2%
  • Itching 2%
  • Leg cramps 2%
More Premarin side effects »
  • Headache 26%
  • Low mood disorder 7%
  • Weight increased 7%
  • Vaginal bleeding between periods 6%
  • Sinus headache 6%
  • Common cold 5%
  • Ear, nose, or throat infection 5%
  • Back pain 5%
  • Neck pain 5%
  • Constipation 4%
More Minivelle side effects »
How it works
PremarinMinivelle
Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.The Minivelle (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
PremarinMinivelle
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Available as
PremarinMinivelle
  • Pill
  • Patch
Used for (click to learn more)
PremarinMinivelle
  • Hot flashes and night sweats
  • Hot flashes and night sweats
Risk factors for serious side effects
PremarinMinivelle
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
      • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Premarin (Conjugated Estrogens) risks & warnings »
      • Using estrogen for more than one year
      • Personal or family history of breast cancer
      • Duration of use
      • Personal or family history of blood clots
      • Obesity
      • Systemic lupus erythematosus (SLE)
      • Smoking
      • Obesity
      • High blood pressure
      • High blood sugar
      • High cholesterol
      • Age 50 or older
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Minivelle (Estradiol Patch) risks & warnings »
      Pregnancy category
      PremarinMinivelle
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
      No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      PremarinMinivelle
      • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
      • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
      • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
      • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
      • Improves mood, energy, and mental alertness for some people.
      • The [name_comon] is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
      • You’ll need to replace it twice a week, every 3 to 4 days.
      • Causes little or no skin irritation and doesn't leave adhesive on your skin.
      • The Minivelle (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
      • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
      • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
      • Improves mood, energy, and mental alertness for some people.
      Downsides and risks
      PremarinMinivelle
      • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
      • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
      • Can be expensive since it's only available as a brand name product.
      • Increases your risk of uterine and breast cancer.
      • Increases your risk of developing blood clots and stroke.
      • Can't be used in people with liver problems.
      • You need to replace the Minivelle (Estradiol Patch) twice a week, compared to other patches that are once a week.
      • Patch can fall off.
      • If you have your uterus, you have to use the Minivelle (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
      • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
      • Increases your risk of uterine and breast cancer.
      • Increases your risk of developing blood clots and stroke.
      • Can't be used in people with liver problems.
      Tips from our pharmacists for people taking the medication
      PremarinMinivelle
      • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
      • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
      • Can cause nausea, dizziness, bloating and breast tenderness.
      • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
      • Tell your doctor about any unusual vaginal bleeding.
      • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
      • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
      • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
      • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
      • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
      • Can cause nausea, dizziness, bloating, and breast tenderness.
      • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
      • Tell your doctor about any unusual vaginal bleeding.
      Learn more
      More about PremarinSide effectsReviews & ratingsAlternativesFDA package insert
      More about MinivelleSide effectsReviews & ratingsAlternativesFDA package insert