Compare Premarin vs. Premarin Vaginal Cream

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin
(Conjugated Estrogens)

Premarin Vaginal Cream
(Conjugated Estrogens)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Relieves vaginal dryness and pain due to menopause. Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.779220779220779Premarin
Reviews for Premarin (Conjugated Estrogens)
50%
of people say Premarin (Conjugated Estrogens) is worth it
43%
say it works well
11%
say it's a big hassle

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Side effects
PremarinPremarin Vaginal Cream
  • Abdominal pain 5%
  • Back pain 4%
  • Muscle weakness 4%
  • Breast pain 4%
  • Passing gas 4%
  • Thick vaginal discharge 3%
  • Vaginal moniliasis 2%
  • Nervousness 2%
  • Itching 2%
  • Leg cramps 2%
More Premarin side effects »
  • Any side effect 8%
  • Abdominal pain 6%
  • Vaginitis 6%
  • Leg cramps 5%
  • Passing gas 4%
  • Thick vaginal discharge 4%
  • Vaginal moniliasis 4%
  • Sinus inflammation 4%
  • Headache 4%
  • Cough increased 3%
More Premarin Vaginal Cream side effects »
How it works
PremarinPremarin Vaginal Cream
Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Premarin Vaginal Cream (Conjugated Estrogens) is a topical medication that replaces estrogen hormones in the vagina to rebuild vaginal tissue and make vaginal sex more comfortable.
Type of medication
PremarinPremarin Vaginal Cream
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Available as
PremarinPremarin Vaginal Cream
  • Pill
  • Vaginal cream, gel, or ointment
Used for (click to learn more)
PremarinPremarin Vaginal Cream
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
Risk factors for serious side effects
PremarinPremarin Vaginal Cream
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
      • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Premarin (Conjugated Estrogens) risks & warnings »
      • Using estrogen for more than one year
      • Personal or family history of breast cancer
      • Duration of use
      • Personal or family history of blood clots
      • Obesity
      • Systemic lupus erythematosus (SLE)
      • Smoking
      • Obesity
      • High blood pressure
      • High blood sugar
      • High cholesterol
      • Age 50 or older
          • Prior severe allergic reaction to Premarin Vaginal Cream (Conjugated Estrogens)
          • Women of childbearing age
          • High levels of triglycerides
          Detailed Premarin Vaginal Cream (Conjugated Estrogens) risks & warnings »
          Pregnancy category
          PremarinPremarin Vaginal Cream
          XFDA pregnancy category (Unsafe)

          Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

          See the FDA package insert
          XFDA pregnancy category (Unsafe)

          Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
          • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
          • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
          • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          PremarinPremarin Vaginal Cream
          • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
          • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
          • Improves mood, energy, and mental alertness for some people.
          • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
          • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
          • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
          • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
          • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
          • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
          Downsides and risks
          PremarinPremarin Vaginal Cream
          • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
          • Increases your risk of uterine and breast cancer.
          • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
          • Increases your risk of developing blood clots and stroke.
          • Can't be used in people with liver problems.
          • Can be expensive since it's only available as a brand name product.
          • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
          • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
          • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
          • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
          Tips from our pharmacists for people taking the medication
          PremarinPremarin Vaginal Cream
          • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
          • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
          • Can cause nausea, dizziness, bloating and breast tenderness.
          • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
          • Tell your doctor about any unusual vaginal bleeding.
          • Your doctor will tell you how often to use Premarin Vaginal Cream (Conjugated Estrogens). If you're taking Premarin Vaginal Cream (Conjugated Estrogens) regularly, use it around the same time each day.
          • Attach the applicator to the tube. Once the dose is measured, insert the applicator deeply into your vagina, and press the plunger to release all the medicine. Clean the applicator after each use.
          • More effective if you use it at bedtime.
          • Consider wearing a panty liner after use.
          • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
          Learn more
          More about PremarinSide effectsReviews & ratingsAlternativesFDA package insert
          More about Premarin Vaginal CreamSide effectsReviews & ratingsAlternativesFDA package insert