Compare Premarin vs. Prempro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin
(Conjugated Estrogens)

Prempro
(Conjugated Estrogens / Medroxyprogesterone Acetate)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Coming soon.
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Reviews & ratings
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Button Group. All currently active
4.779220779220779Premarin
Reviews for Premarin (Conjugated Estrogens)
50%
of people say Premarin (Conjugated Estrogens) is worth it
43%
say it works well
11%
say it's a big hassle

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Side effects
PremarinPrempro
  • Abdominal pain 5%
  • Back pain 4%
  • Muscle weakness 4%
  • Breast pain 4%
  • Passing gas 4%
  • Thick vaginal discharge 3%
  • Vaginal moniliasis 2%
  • Nervousness 2%
  • Itching 2%
  • Leg cramps 2%
More Premarin side effects »

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
How it works
PremarinPrempro
Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Coming soon.
Type of medication
PremarinPrempro
Hormone replacement
Estrogen derivative
Prescription only
Coming soon.
Available as
PremarinPrempro
  • Pill
  • Pill
Used for (click to learn more)
PremarinPrempro
  • Hot flashes and night sweats
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
Risk factors for serious side effects
PremarinPrempro
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
      • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Premarin (Conjugated Estrogens) risks & warnings »
      Coming soon.
      Pregnancy category
      PremarinPrempro
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
      No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      PremarinPrempro
      • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
      • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
      • Improves mood, energy, and mental alertness for some people.
      • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
      • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
      Coming soon.
      Downsides and risks
      PremarinPrempro
      • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
      • Increases your risk of uterine and breast cancer.
      • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
      • Increases your risk of developing blood clots and stroke.
      • Can't be used in people with liver problems.
      • Can be expensive since it's only available as a brand name product.
      Coming soon.
      Tips from our pharmacists for people taking the medication
      PremarinPrempro
      • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
      • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
      • Can cause nausea, dizziness, bloating and breast tenderness.
      • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
      • Tell your doctor about any unusual vaginal bleeding.
      Coming soon.
      Learn more
      More about PremarinSide effectsReviews & ratingsAlternativesFDA package insert
      More about PremproSide effectsReviews & ratingsFDA package insert