Compare Premarin vs. Provera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin
(conjugated estrogens)

Provera
(medroxyprogesterone)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.78Premarin
Reviews for Premarin
50%
of people (All ages) say Premarin is worth it
43%
say it works well
11%
say it's a big hassle
154 reviews
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Have you used Provera (medroxyprogesterone)?
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Side effects
PremarinProvera
  • Vaginal hemorrhage 13%
  • Abdominal pain 5%
  • Breast pain 3%
  • Flatulence 4%
  • Pain 1%
  • Leukorrhea 3%
  • Endometrial hyperplasia 5%
  • Vaginitis 5%
  • Insomnia 1%
More Premarin side effects »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
How it works
PremarinProvera
Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.
Type of medication
PremarinProvera
Prescription onlyPrescription only
Available as
PremarinProvera
  • Pill
  • Pill
Used for
PremarinProvera
  • Hot Flashes And Night Sweats
  • Amenorrhea
Risk factors for serious side effects
PremarinProvera
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Premarin (conjugated estrogens) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed Provera (medroxyprogesterone) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Pain
PremarinProvera
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
No pain related info.
Weight
PremarinProvera
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
Upsides and benefits
PremarinProvera
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
Downsides and risks
PremarinProvera
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
Tips from our pharmacists for people taking the medication
PremarinProvera
  • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
  • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
  • Tell your doctor about any unusual vaginal bleeding.
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
Learn more
More about PremarinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Premarin (conjugated estrogens)?
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More about ProveraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it