Compare Premarin vs. Vivelle-Dot

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Premarin
(conjugated estrogens)

Vivelle-Dot
(estradiol patch)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. The Vivelle-Dot (Estradiol Patch) needs to be replaced twice a week, but it comes in more strengths than other patches. It may have fewer side effects than oral estrogen pills.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.78Premarin
Reviews for Premarin (conjugated estrogens)
50%
of people (All ages) say Premarin (conjugated estrogens) is worth it
43%
say it works well
11%
say it's a big hassle
154 reviews
Have you used Premarin (conjugated estrogens)?
Worth itNot sureNot worth it
Reviews for Vivelle-Dot (estradiol patch)
Not enough review data. Review it!
+50% better vs. Premarin (conjugated estrogens)
Not enough review data. Review it!
+46% better vs. Premarin (conjugated estrogens)
Not enough review data. Review it!
+11% better vs. Premarin (conjugated estrogens)
Have you used Vivelle-Dot (estradiol patch)?
Worth itNot sureNot worth it
Side effects
PremarinVivelle-Dot
  • Excessive vaginal bleeding 13%
  • Abdominal pain 5%
  • Breast pain 3%
  • Passing gas 4%
  • Pain 1%
  • Thick vaginal discharge 3%
  • Endometrial hyperplasia 5%
  • Vaginitis 5%
  • Sleep difficulty 1%
More Premarin side effects »
  • Breast tenderness 17%
  • Low mood disorder 7%
  • Back pain 3%
  • Weight increased 7%
  • Indigestion 3%
More Vivelle-Dot side effects »
How it works
PremarinVivelle-Dot
Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.The Vivelle-Dot (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
PremarinVivelle-Dot
Prescription only
Prescription only
Available as
PremarinVivelle-Dot
  • Pill
  • Patch
Used for
PremarinVivelle-Dot
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
PremarinVivelle-Dot
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Premarin (conjugated estrogens) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Vivelle-Dot (estradiol patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Pain
PremarinVivelle-Dot
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
No pain related info.
Weight
PremarinVivelle-Dot
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
PremarinVivelle-Dot
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • Comes in 4 different strengths.
  • The Vivelle-Dot (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
PremarinVivelle-Dot
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
  • You need to replace the Vivelle-Dot (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Vivelle-Dot (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
Tips from our pharmacists for people taking the medication
PremarinVivelle-Dot
  • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
  • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
  • Tell your doctor about any unusual vaginal bleeding.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about PremarinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Premarin (conjugated estrogens)?
Worth itNot sureNot worth it
More about Vivelle-DotSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vivelle-Dot (estradiol patch)?
Worth itNot sureNot worth it