Compare Premarin vs. Vivelle-Dot

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

3.5/ 5 average rating with 154 reviewsforPremarin
Relieves menopausal symptoms.

Vivelle-Dot (Estradiol patch) is an estrogen patch that may be easier and more convenient to use than the pill or gel form.

Upsides
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • Good choice if you want to avoid daily dosing of the pill or gel form.
  • Available in wider variety of strengths compared to other estrogen patches.
Downsides
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
  • Other estrogen patches are dosed once weekly and may be more convenient than Vivelle-Dot (Estradiol patch).
  • Patches can fall off.
  • Estrogen therapy is associated with serious risks for uterine cancer, breast cancer, and blood clots. Don't start treatment until you have had a thorough discussion of the risks and benefits with your doctor.
Used for
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
  • Advanced prostate cancer
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Prevention of osteoporosis in menopausal women
Dosage forms
  • Pill
  • Patch
Price
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Reviews
154 reviews so far
50%
saidit'sworth it
43%
saiditworked well
11%
saidit'sa big hassle

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Side effects
28possible side effects
  • Headache
    13%
  • Abdominal pain
    9%
  • Breast pain
    7%
  • Nausea
    5%
  • Asthenia
    4%
  • Back pain
    4%
  • Pain
    4%
  • Flatulence
    4%
  • Insomnia
    4%
  • Leukorrhea
    4%
  • Vaginal moniliasis
    4%
  • Leg cramps
    3%
  • Depression
    3%
  • Pruritus
    3%
  • Vaginitis
    3%
  • Pelvic pain
    2%
  • Hypertension
    2%
  • Diarrhea
    2%
  • Dyspepsia
    2%
  • Weight gain
    2%
  • Emotional lability
    2%
  • Hypertonia
    2%
  • Acne
    2%
  • Alopecia
    2%
  • Breast enlargement
    2%
  • Breast neoplasm
    2%
  • Cervix disorder
    2%
  • Vaginal hemorrhage
    2%
See more detailed side effects
20possible side effects
  • Headache
    26%
  • Breast pain
    13%
  • Back pain
    11%
  • Menstrual bleeding
    11%
  • Influenza
    8%
  • Common cold
    8%
  • Nausea
    5%
  • Pain
    5%
  • Sinus infection
    5%
  • Lung infection
    5%
  • Neck pain
    5%
  • Limb pain
    5%
  • Nasal congestion
    5%
  • Joint pain
    4%
  • Depression
    3%
  • Constipation
    2%
  • Flu-like symptoms
    2%
  • Sinus headache
    2%
  • Anxiety
    2%
  • Trouble sleeping
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Memory loss
  • Gallbladder problems
  • Serious allergic reaction
    • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Uterine cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings