Compare Prempro vs. Climara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prempro
(conjugated estrogens / medroxyprogesterone acetate)

Climara
(estradiol patch)

Coming soon.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Climara (estradiol patch) is a treatment for low estrogen that is used only once weekly, and it may have fewer side effects than oral estrogen pills.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Climara (estradiol patch)?
Worth itNot sureNot worth it
Side effects
PremproClimara

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Breast pain 1%
  • Sinus infection 1%
  • Stuffy nose 1%
  • Swelling of arms and legs 7%
  • Stomach pain 3%
  • Pain 1%
More Climara side effects »
How it works
PremproClimara
Coming soon.The Climara (estradiol patch) replaces estrogen that your body loses during and after menopause. Higher levels of estrogen help relieve symptoms of menopause and prevent bone loss.
Type of medication
PremproClimara
Prescription only
Available as
PremproClimara
  • Pill
  • Patch
Used for
PremproClimara
  • Menopause Moderate To Severe Abnormal Vasomotor Function Menopause Moderate To Severe Vaginal Atrophy Moderate To Severe Vulvar Atrophy Postmenopausal Osteoporosis
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
PremproClimara
    Coming soon.
    • Using estrogen for more than one year
    • Personal or family history of breast cancer
    • Personal or family history of blood clots
    • Smoking
    Detailed Climara (estradiol patch) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Weight
    PremproClimara
    No weight related info.
    • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
    Upsides and benefits
    PremproClimara
    Coming soon
    • Climara (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
    • The patch is good for people who don't want to or can't take daily pills.
    • Climara (estradiol patch) is available as a generic product, which lowers the cost.
    • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
    • Lowers your risk of fractures by keeping your bones healthy.
    Downsides and risks
    PremproClimara
    Coming soon
    • The patch can fall off, especially if you like to regularly swim, take baths or use saunas or steamrooms.
    • Increases your risk of uterine and breast cancer.
    • If you have your uterus, you have to use the Climara (estradiol patch) with another hormone called progestin to lower your risk of uterine cancer.
    • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, underactive thyroid and migraines.
    • If you're only having vaginal dryness or inflammation and not hot flashes, it's better to use creams that you can apply to the affected area instead of Climara (estradiol patch).
    Tips from our pharmacists for people taking the medication
    PremproClimara
    Coming soon
    • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
    • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly or the upper areas of your buttocks as directed by the manufacturer. Don't put it on your waistline or on your breasts. Press the patch firmly in place for at least 10 seconds, especially around the edges.
    • Replace the patch every 7 days on a different area of your skin to prevent skin irritation.
    • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
    • Should not be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.
    Learn more
    More about PremproSide effectsReviews & ratingsFDA package insert
    Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
    Worth itNot sureNot worth it
    More about ClimaraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Climara (estradiol patch)?
    Worth itNot sureNot worth it