Compare Prempro vs. Combipatch
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.
- Twice weekly patch. Good for people who don't want to take daily pills.
- Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
- Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
- Good for women with an intact uterus.
- You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
- More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
- You may get irregular bleeding and spotting that can last a few months to a year.
- The patch can't be exposed to direct sunlight for long periods of time.
- Can be expensive since it's only available as a brand name product.
- Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
- In women with an intact uterus; Prophylaxis
- Hot flashes
- Vaginal dryness and inflammation
- Low estrogen
- Primary ovarian failure
- Breast pain34%
- Menstrual cramps30%
- Skin irritation20%
- Stuffy nose19%
- Menstrual problems17%
- Back pain15%
- Flu like symptoms14%
- Endometrial cancer
Using estrogen for more than one year
- Breast cancer
Personal or family history of breast cancer
...and 1 more risk factors
- Increased risk of blood clots and stroke
Personal or family history of blood clots
...and 3 more risk factors
Aged 65 or older
- Pancreas swelling (pancreatitis)
High levels of triglycerides