Compare Prempro vs. Divigel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prempro
(conjugated estrogens / medroxyprogesterone acetate)

Divigel
(estradiol gel)

Coming soon.Relieves hot flashes due to menopause. Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Prempro (conjugated estrogens / medroxyprogesterone acetate)
Not enough review data. Review it!
of people (All ages) say Prempro (conjugated estrogens / medroxyprogesterone acetate) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
Worth itNot sureNot worth it
Reviews for Divigel (estradiol gel)
Not enough review data. Review it!
Same vs. Prempro (conjugated estrogens / medroxyprogesterone acetate)
Not enough review data. Review it!
Same vs. Prempro (conjugated estrogens / medroxyprogesterone acetate)
Not enough review data. Review it!
Same vs. Prempro (conjugated estrogens / medroxyprogesterone acetate)
Have you used Divigel (estradiol gel)?
Worth itNot sureNot worth it
Side effects
PremproDivigel

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Common cold 2%
  • Ear, nose, or throat infection 4%
  • Metrorrhagia 2%
  • Breast tenderness 1%
More Divigel side effects »
How it works
PremproDivigel
Coming soon.Divigel (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
PremproDivigel
Prescription only
Available as
PremproDivigel
  • Pill
  • Cream, gel, or ointment
Used for
PremproDivigel
  • Menopause Moderate To Severe Abnormal Vasomotor Function Menopause Moderate To Severe Vaginal Atrophy Moderate To Severe Vulvar Atrophy Postmenopausal Osteoporosis
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
PremproDivigel
    Coming soon.
    • Using estrogen for more than one year
    • Personal or family history of breast cancer
    • Duration of use
    • Personal or family history of blood clots
    • Obesity
    Detailed Divigel (estradiol gel) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Alcohol
    PremproDivigel
    No alcohol related info.
    • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Weight
    PremproDivigel
    No weight related info.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    Upsides and benefits
    PremproDivigel
    Coming soon
    • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
    • Good for people who don't want to take daily pills.
    • The pre-measured packets are easy to use and can be taken anywhere.
    • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
    • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
    • Divigel (Estradiol Gel) is available in 3 strengths.
    • Very few women (less than 1%) had skin irritation from the medicine.
    • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    Downsides and risks
    PremproDivigel
    Coming soon
    • Increases your risk of endometrial and breast cancer.
    • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • It's possible to expose other people to the estrogen before it's absorbed by your skin.
    • Can be expensive since it's only available as a brand name product.
    Tips from our pharmacists for people taking the medication
    PremproDivigel
    Coming soon
    • Apply all of the gel in the packet to dry, clean, unbroken skin on the right or left upper thigh, alternating each day.
    • Don't put it on your face, breasts, vagina, or irritated skin.
    • Don't rub it in. Let the gel dry before dressing, and don't wash the application site for at least an hour.
    • Wash your hands well after applying the gel.
    • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    Learn more
    More about PremproSide effectsReviews & ratingsFDA package insert
    Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
    Worth itNot sureNot worth it
    More about DivigelSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Divigel (estradiol gel)?
    Worth itNot sureNot worth it