Compare Prempro vs. Elestrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prempro
(Conjugated Estrogens / Medroxyprogesterone Acetate)

Elestrin
(Estradiol Gel)

Coming soon.Relieves hot flashes due to menopause. Elestrin (Estradiol Gel) is easy to use, absorbs well into your skin, and is a good option if you don’t want to use estrogen pills or patches.
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Reviews & ratings
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Side effects
PremproElestrin

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Metrorrhagia 7%
  • Breast tenderness 4%
  • Common cold 3%
  • Ear, nose, or throat infection 2%
More Elestrin side effects »
How it works
PremproElestrin
Coming soon.Elestrin (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
PremproElestrin
Coming soon.
Hormone replacement
Estrogen derivative
Prescription only
Available as
PremproElestrin
  • Pill
  • Cream, gel, or ointment
Used for (click to learn more)
PremproElestrin
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • Hot flashes and night sweats
Risk factors for serious side effects
PremproElestrin
Coming soon.
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
    Detailed Elestrin (Estradiol Gel) risks & warnings »
    Pregnancy category
    PremproElestrin
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    PremproElestrin
    Coming soon.
    • Elestrin (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
    • Good for people who don't want to take daily pills.
    • The pre-measured packets are easy to use and can be taken anywhere.
    • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
    • In studies, when people used low doses of Elestrin (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Elestrin (Estradiol Gel) felt better in just 2 weeks.
    • Elestrin (Estradiol Gel) is available in 3 strengths.
    • Very few women (less than 1%) had skin irritation from the medicine.
    • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    Downsides and risks
    PremproElestrin
    Coming soon.
    • Increases your risk of endometrial and breast cancer.
    • If you have your uterus, you have to use Elestrin (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • It's possible to expose other people to the estrogen before it's absorbed by your skin.
    • Can be expensive since it's only available as a brand name product.
    Tips from our pharmacists for people taking the medication
    PremproElestrin
    Coming soon.
    • Apply to your upper arm and shoulder area after a bath or shower.
    • Don't put it on your face, breasts, vagina, or irritated skin.
    • Don't rub it in. Let the gel dry before dressing, and don't get the application site wet for at least 2 hours.
    • Wash your hands well after applying the gel.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    Learn more
    More about PremproSide effectsReviews & ratingsFDA package insert
    More about ElestrinSide effectsReviews & ratingsAlternativesFDA package insert