Elestrin (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
› Estrogen derivative
Cream, gel, or ointment
Used for (click to learn more)
› Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
› Elestrin (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
› Good for people who don't want to take daily pills.
› The pre-measured packets are easy to use and can be taken anywhere.
› Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
› In studies, when people used low doses of Elestrin (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Elestrin (Estradiol Gel) felt better in just 2 weeks.
› Elestrin (Estradiol Gel) is available in 3 strengths.
› Very few women (less than 1%) had skin irritation from the medicine.
› Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
› Improves mood, energy, and mental alertness for some people.
Downsides and risks
› Increases your risk of endometrial and breast cancer.
› If you have your uterus, you have to use Elestrin (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
› Increases your risk of developing blood clots and stroke.
› Can't be used in people with liver problems.
› It's possible to expose other people to the estrogen before it's absorbed by your skin.
› Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
› Apply to your upper arm and shoulder area after a bath or shower.
› Don't put it on your face, breasts, vagina, or irritated skin.
› Don't rub it in. Let the gel dry before dressing, and don't get the application site wet for at least 2 hours.
› Wash your hands well after applying the gel.
› Can cause nausea, dizziness, bloating, and breast tenderness.
› Tell your doctor about any unusual vaginal bleeding.
› Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.