Compare Prempro vs. Estradiol Norethindrone
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.
- Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
- Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
- Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
- Improves mood, energy, and mental alertness for some people.
- Mimvey brand is less expensive than other estrogen/progestin combination medicines.
- More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
- Increases your risk of developing blood clots and stroke.
- You may get irregular bleeding and spotting that can last a few months to a year.
- Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
- In women with an intact uterus; Prophylaxis
- Hot flashes and night sweats
- Vaginal dryness and inflammation
- Prevention of postmenopausal osteoporosis
- Breast Pain24%
- Upper Respiratory Tract Infection18%
- Back Pain6%
- Post-Menopausal Bleeding5%
- Uterine Fibroid5%
- Infection Viral4%
- Moniliasis Genital4%
- Endometrial cancer
Using estrogen for more than one year
- Breast cancer
Personal or family history of breast cancer
...and 1 more risk factors
- Increased risk of blood clots and stroke
Personal or family history of blood clots
...and 2 more risk factors
- Harm to fetus
Women of childbearing age
- Pancreas swelling (pancreatitis)
High levels of triglycerides
- Ovarian cancer
Family history of ovarian cancer