Compare Prempro vs. Estradiol Patch

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prempro
(conjugated estrogens / medroxyprogesterone acetate)

Estraderm
(estradiol patch)

Coming soon.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. The Estraderm (Estradiol Patch) needs to be replaced twice a week, and it may have fewer side effects than oral estrogen pills.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Estraderm (estradiol patch)?
Worth itNot sureNot worth it
Side effects
PremproEstradiol Patch

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Breast pain 1%
  • Sinusitis 1%
  • Rhinitis 1%
  • Edema 7%
  • Abdominal pain 3%
  • Pain 1%
More Estradiol Patch side effects »
How it works
PremproEstradiol Patch
Coming soon.The Estraderm (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
PremproEstradiol Patch
Prescription only
Available as
PremproEstradiol Patch
  • Pill
  • Patch
Used for
PremproEstradiol Patch
  • Menopause Moderate To Severe Abnormal Vasomotor Function Menopause Moderate To Severe Vaginal Atrophy Moderate To Severe Vulvar Atrophy Postmenopausal Osteoporosis
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
PremproEstradiol Patch
    Coming soon.
    • Using estrogen for more than one year
    • Personal or family history of breast cancer
    • Duration of use
    • Personal or family history of blood clots
    • Obesity
    Detailed Estraderm (estradiol patch) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Weight
    PremproEstradiol Patch
    No weight related info.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    Upsides and benefits
    PremproEstradiol Patch
    Coming soon
    • The Estraderm (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
    • The patch is good for people who don't want to take daily pills.
    • Can be worn while swimming, bathing, and showering.
    • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
    • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    Downsides and risks
    PremproEstradiol Patch
    Coming soon
    • Only comes in 2 strengths.
    • You need to replace the Estraderm (Estradiol Patch) twice a week, compared to other patches that are once a week.
    • Patch can fall off.
    • Increases your risk of uterine and breast cancer.
    • If you have your uterus, you have to use the Estraderm (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
    • Can't be used in people with liver problems.
    Tips from our pharmacists for people taking the medication
    PremproEstradiol Patch
    Coming soon
    • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
    • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
    • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
    • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
    • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    Learn more
    More about PremproSide effectsReviews & ratingsFDA package insert
    Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
    Worth itNot sureNot worth it
    More about Estradiol PatchSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Estraderm (estradiol patch)?
    Worth itNot sureNot worth it