Compare Prempro vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate)

No information currently available
Relieves vaginal dryness due to menopause.

Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.

4.4/ 7 average rating with 56 reviewsforEstring
No information currently available
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
No information currently available
  • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • In women with an intact uterus; Prophylaxis
  • Vaginal dryness and inflammation
Dosage forms
  • Pill
  • Vaginal ring
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Side effects
The Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
  • Leukorrhea
  • Back Pain
  • Genital Moniliasis
  • Upper Respiratory Tract Infection
  • Vaginitis
  • Vaginal Discomfort/Pain
  • Arthritis
  • Insomnia
  • Abdominal Pain
See more detailed side effects
Risks and warnings
No information currently available
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 2 more risk factors

  • Increased risk of heart disease


    ...and 5 more risk factors

  • Harm to fetus

    Women of childbearing age

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings