Compare Prempro vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prempro
(conjugated estrogens / medroxyprogesterone acetate)

Estring
(estradiol vaginal ring)

Coming soon.Relieves vaginal dryness due to menopause. Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.
Reviews & ratings
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Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
Worth itNot sureNot worth it
Reviews for Estring
63%
-13% worse vs. Prempro
39%
+11% better vs. Prempro
18%
+18% better vs. Prempro
Have you used Estring (estradiol vaginal ring)?
Worth itNot sureNot worth it
Side effects
PremproEstring

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Headache 13%
  • Thick vaginal discharge 7%
  • Back pain 6%
  • Yeast infection 6%
  • Ear, nose, or throat infection 5%
  • Vaginitis 5%
  • Vaginal discomfort/pain 5%
  • Sinus inflammation 4%
  • Asymptomatic genital bacterial growth 4%
  • Abdominal pain 4%
More Estring side effects »
How it works
PremproEstring
Coming soon.Estring (Estradiol Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.
Type of medication
PremproEstring
Prescription only
Available as
PremproEstring
  • Pill
  • Vaginal ring
Used for
PremproEstring
  • Menopause Moderate To Severe Abnormal Vasomotor Function Menopause Moderate To Severe Vaginal Atrophy Moderate To Severe Vulvar Atrophy Postmenopausal Osteoporosis
  • Vaginal Dryness And Inflammation
Risk factors for serious side effects
PremproEstring
    Coming soon.
    • Using estrogen for more than one year
    • Personal or family history of breast cancer
    • Duration of use
    • Personal or family history of blood clots
    • Obesity
    Detailed Estring (estradiol vaginal ring) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Upsides and benefits
    PremproEstring
    Coming soon
    • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
    • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
    • Good option for people who don't want to take oral pills.
    • Generally works well with fewer side effects.
    • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
    • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
    • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
    Downsides and risks
    PremproEstring
    Coming soon
    • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
    • The ring can fall out without you noticing it.
    • Increases your risk of endometrial (uterine cancer).
    • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
    • Can be expensive since it's only available as a brand name product.
    Tips from our pharmacists for people taking the medication
    PremproEstring
    Coming soon
    • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
    • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
    • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
    • It can take up to 2 to 3 weeks to feel the full benefits.
    • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
    • Tell your doctor about any unusual vaginal bleeding.
    Learn more
    More about PremproSide effectsReviews & ratingsFDA package insert
    Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
    Worth itNot sureNot worth it
    More about EstringSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Estring (estradiol vaginal ring)?
    Worth itNot sureNot worth it